DNM1L

From Wikipedia, the free encyclopedia

Dynamin 1-like

Identifiers

DNM1L; DRP1; DLP1; DVLP; DYMPLE; HDYNIV; VPS1

External IDs

OMIM: 603850 MGI: 1921256 HomoloGene: 6384

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding • hydrolase activity
Cellular Component:	• endoplasmic reticulum • cis-Golgi network • membrane
Biological Process:	• endocytosis • mitochondrial membrane organization and biogenesis • cell communication • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005690 (mRNA)
NP_005681 (protein)

NM_001025947 (mRNA)
NP_001021118 (protein)

Location

Chr 12: 32.72 - 32.79 Mb

Chr 16: 16.23 - 16.27 Mb

Pubmed search

[1]

[2]

Dynamin 1-like, also known as DNM1L, is a human gene.^[1]

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.^[1]

[edit] References

^ ^a ^b Entrez Gene: DNM1L dynamin 1-like.

[edit] Further reading

Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9. PMID 17718388.
Shin HW, Shinotsuka C, Torii S, et al. (1998). "Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p.". J. Biochem. 122 (3): 525–30. PMID 9348079.
Kamimoto T, Nagai Y, Onogi H, et al. (1998). "Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells.". J. Biol. Chem. 273 (2): 1044–51. PMID 9422767.
Imoto M, Tachibana I, Urrutia R (1998). "Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p.". J. Cell. Sci. 111 ( Pt 10): 1341–9. PMID 9570752.
Hong YR, Chen CH, Cheng DS, et al. (1998). "Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.". Biochem. Biophys. Res. Commun. 249 (3): 697–703. doi:10.1006/bbrc.1998.9253. PMID 9731200.
Rasmussen RK, Rusak J, Price G, et al. (1998). "Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid.". Biochem. J. 335 ( Pt 1): 119–24. PMID 9742220.
Smirnova E, Shurland DL, Ryazantsev SN, van der Bliek AM (1998). "A human dynamin-related protein controls the distribution of mitochondria.". J. Cell Biol. 143 (2): 351–8. PMID 9786947.
Smirnova E, Griparic L, Shurland DL, van der Bliek AM (2002). "Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells.". Mol. Biol. Cell 12 (8): 2245–56. PMID 11514614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Karbowski M, Lee YJ, Gaume B, et al. (2003). "Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.". J. Cell Biol. 159 (6): 931–8. doi:10.1083/jcb.200209124. PMID 12499352.
Koch A, Thiemann M, Grabenbauer M, et al. (2003). "Dynamin-like protein 1 is involved in peroxisomal fission.". J. Biol. Chem. 278 (10): 8597–605. doi:10.1074/jbc.M211761200. PMID 12499366.
Li X, Gould SJ (2003). "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11.". J. Biol. Chem. 278 (19): 17012–20. doi:10.1074/jbc.M212031200. PMID 12618434.
Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC (2003). "Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.". J. Cell Biol. 160 (7): 1115–27. doi:10.1083/jcb.200212059. PMID 12668660.
Yoon Y, Krueger EW, Oswald BJ, McNiven MA (2003). "The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.". Mol. Cell. Biol. 23 (15): 5409–20. PMID 12861026.
Howng SL, Sy WD, Cheng TS, et al. (2004). "Genomic organization, alternative splicing, and promoter analysis of human dynamin-like protein gene.". Biochem. Biophys. Res. Commun. 314 (3): 766–72. PMID 14741701.
Lee YJ, Jeong SY, Karbowski M, et al. (2005). "Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.". Mol. Biol. Cell 15 (11): 5001–11. doi:10.1091/mbc.E04-04-0294. PMID 15356267.
Pitts KR, McNiven MA, Yoon Y (2005). "Mitochondria-specific function of the dynamin family protein DLP1 is mediated by its C-terminal domains.". J. Biol. Chem. 279 (48): 50286–94. doi:10.1074/jbc.M405531200. PMID 15364948.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Germain M, Mathai JP, McBride HM, Shore GC (2005). "Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.". EMBO J. 24 (8): 1546–56. doi:10.1038/sj.emboj.7600592. PMID 15791210.
Narayanan R, Leonard M, Song BD, et al. (2005). "An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function.". J. Cell Biol. 169 (1): 117–26. doi:10.1083/jcb.200502042. PMID 15824135.