DNA assembly

From Wikipedia, the free encyclopedia

DNA assembly is the process of putting fragments of DNA that have been sequenced into their correct chromosomal positions. The pieces of DNA are assembled to reconstitute the sequence of the chromosome from which they came. In the past this process was made by hand but today the scientists are using complex software to speed up the process.

Due to errors in the sequencing process, the fragments don't always match. The places where the sequences don't match are marked in red stripes. The operator must manually correct the values in those places. This is why the process can't be fully automatic.

Using 'Local alignment' and 'Global alignment' mathematical algorithms, programs like DNA Baser can now automatically assemble 10 or more fragments in only few seconds instead of hours or days.

Example of assembled sequences: example1 example12