DNAJC1

From Wikipedia, the free encyclopedia

DnaJ (Hsp40) homolog, subfamily C, member 1

PDB rendering based on 2cqq.

Available structures: 2cqq, 2cqr

Identifiers

Symbol(s)

DNAJC1; DNAJL1; ERdj1; HTJ1; MGC131954

External IDs

MGI: 103268 HomoloGene: 7293

Gene ontology
Molecular Function:	• ATPase activator activity • DNA binding • Hsp70/Hsc70 protein regulator activity • heat shock protein binding • ribosome binding • unfolded protein binding • chaperone binding
Cellular Component:	• nucleus • endoplasmic reticulum • endoplasmic reticulum lumen • microsome • membrane • integral to membrane
Biological Process:	• protein folding • negative regulation of proteolysis • regulation of protein secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022365 (mRNA)
NP_071760 (protein)

NM_007869 (mRNA)
NP_031895 (protein)

Location

Chr 10: 22.09 - 22.33 Mb

Chr 2: 18.12 - 18.31 Mb

Pubmed search

[1]

[2]

DnaJ (Hsp40) homolog, subfamily C, member 1, also known as DNAJC1, is a human gene.^[1]

[edit] References

^ Entrez Gene: DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1.

[edit] Further reading

Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.". Biochem. Biophys. Res. Commun. 338 (3): 1467-77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.". J. Biol. Chem. 279 (12): 11432-43. doi:10.1074/jbc.M310903200. PMID 14668352.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chevalier M, Rhee H, Elguindi EC, Blond SY (2000). "Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1.". J. Biol. Chem. 275 (26): 19620-7. doi:10.1074/jbc.M001333200. PMID 10777498.