DLX2

From Wikipedia, the free encyclopedia

Distal-less homeobox 2

PDB rendering based on 2djn.

Available structures: 2djn

Identifiers

Symbol(s)

DLX2; TES-1; TES1

External IDs

OMIM: 126255 MGI: 94902 HomoloGene: 3244

Gene ontology
Molecular Function:	• chromatin binding • transcription factor activity • single-stranded RNA binding • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • brain development • cell differentiation • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004405 (mRNA)
NP_004396 (protein)

NM_010054 (mRNA)
NP_034184 (protein)

Location

Chr 2: 172.67 - 172.68 Mb

Chr 2: 71.34 - 71.35 Mb

Pubmed search

[1]

[2]

Distal-less homeobox 2, also known as DLX2, is a human gene.^[1]

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.^[1]

[edit] References

^ ^a ^b Entrez Gene: DLX2 distal-less homeobox 2.

[edit] Further reading

Harris SE, Guo D, Harris MA, et al. (2003). "Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors.". Front. Biosci. 8: s1249–65. PMID 12957859.
Ozçelik T, Porteus MH, Rubenstein JL, Francke U (1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2.". Genomics 13 (4): 1157–61. PMID 1354641.
Qiu M, Bulfone A, Martinez S, et al. (1995). "Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.". Genes Dev. 9 (20): 2523–38. PMID 7590232.
Selski DJ, Thomas NE, Coleman PD, Rogers KE (1993). "The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue.". Gene 132 (2): 301–3. PMID 7901126.
Simeone A, Acampora D, Pannese M, et al. (1994). "Cloning and characterization of two members of the vertebrate Dlx gene family.". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2250–4. PMID 7907794.
McGuinness T, Porteus MH, Smiga S, et al. (1996). "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus.". Genomics 35 (3): 473–85. doi:10.1006/geno.1996.0387. PMID 8812481.
Zhang H, Hu G, Wang H, et al. (1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism.". Mol. Cell. Biol. 17 (5): 2920–32. PMID 9111364.
Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins.". Brain Res. Dev. Brain Res. 130 (2): 217–30. PMID 11675124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Espinoza HM, Ganga M, Vadlamudi U, et al. (2005). "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein.". Biochemistry 44 (10): 3942–54. doi:10.1021/bi048362x. PMID 15751970.