DLX1

From Wikipedia, the free encyclopedia

Distal-less homeobox 1

Identifiers

External IDs

OMIM: 600029 MGI: 94901 HomoloGene: 22558

Gene ontology
Molecular Function:	• DNA binding • chromatin binding • transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • cell differentiation • negative regulation of neuron apoptosis

Orthologs

Human

Mouse

Refseq

NM_001038493 (mRNA)
NP_001033582 (protein)

NM_010053 (mRNA)
NP_034183 (protein)

Location

Chr 2: 172.66 - 172.66 Mb

Chr 2: 71.33 - 71.33 Mb

Pubmed search

[1]

[2]

Distal-less homeobox 1, also known as DLX1, is a human gene.^[1]

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: DLX1 distal-less homeobox 1.

[edit] Further reading

Simeone A, Acampora D, Pannese M, et al. (1994). "Cloning and characterization of two members of the vertebrate Dlx gene family.". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2250–4. PMID 7907794.
Letinic K, Zoncu R, Rakic P (2002). "Origin of GABAergic neurons in the human neocortex.". Nature 417 (6889): 645–9. doi:10.1038/nature00779. PMID 12050665.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chiba S, Takeshita K, Imai Y, et al. (2004). "Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells.". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15577–82. doi:10.1073/pnas.2536757100. PMID 14671321.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhou QP, Le TN, Qiu X, et al. (2004). "Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation.". Nucleic Acids Res. 32 (3): 884–92. doi:10.1093/nar/gkh233. PMID 14769946.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hamilton SP, Woo JM, Carlson EJ, et al. (2006). "Analysis of four DLX homeobox genes in autistic probands.". BMC Genet. 6: 52. doi:10.1186/1471-2156-6-52. PMID 16266434.