DLG4

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Discs, large homolog 4 (Drosophila)
PDB rendering based on 1be9.
Available structures: 1be9, 1bfe, 1iu0, 1iu2, 1jxm, 1jxo, 1kef, 1kjw, 1qlc, 1rgr, 1tp3, 1tp5, 1tq3, 1zok
Identifiers
Symbol(s)	DLG4; PSD95; SAP90
External IDs	OMIM: 602887 MGI: 1277959 HomoloGene: 1047
Gene ontology Molecular Function: • protein binding • protein C-terminus binding Cellular Component: • cortical cytoskeleton • postsynaptic membrane Biological Process: • protein complex assembly • signal transduction • synaptic transmission • nervous system development • learning
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1742	13385
Ensembl	ENSG00000132535	ENSMUSG00000020886
Uniprot	P78352	Q6XVF4
Refseq	NM_001365 (mRNA) NP_001356 (protein)	XM_993410 (mRNA) XP_998504 (protein)
Location	Chr 17: 7.03 - 7.06 Mb	Chr 11: 69.84 - 69.86 Mb
Pubmed search	[1]	[2]

Discs, large homolog 4 (Drosophila), also known as DLG4, is a human gene.

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.^[1]

[edit] References