Talk:Dizocilpine

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[edit] Olney's lesions?

The article sats this: "MK-801 had a promising future as a neuroprotective agent until neurotoxic-like effects were seen in certain brain regions." Does this have to do with Olney's lesions or something else? If so, I can cite this, but otherwise, we need a citation for this. Jolb 21:34, 7 January 2007 (UTC)

The harm I know of that MK801 causes is neurovacuolization. And there could be other studies that found toxicity. I know MK801 didn't do too hot in clinical trials because it has poor tolerability, e.g. causing intense, unpleasant aural hallucinations. Here's the ref I've found for the vacuolization thing, I'll go ahead and add it in:

Olney J, Labruyerre J and Price MT. 1989. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Sciencel, Volume 244, Issue 4910, Pages 1360-1362. Accessed January 7, 2007.

delldot | talk

Here's another ref: Ellison G. 1995. The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain Research. Brain Research Reviews. Volume 20, Issue 2, Pages 250-267. Accessed January 7, 2007.

delldot | talk

And another:

Hargreaves RJ, Hill RG, Iversen LL. 1994. NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. Acta Neurochir Suppl (Wien). 1994;60:15-9. Accessed January 7, 2007.

I dunno, should I add this one in too, or would that be overkill? delldot | talk 23:49, 7 January 2007 (UTC)

Only the link in your second post works for me. The other two link to a search page. Anyway it does seem that these are what I thought, Olney's Lesions. I'm no expert, so you take a look and see if you agree that these are the same... Jolb 02:04, 9 January 2007 (UTC)

Huh, weird. I can't get the links to work. I don't know what's going on. Have you heard of that happening before, linking to a pubmed source and it not being there? delldot | talk 07:52, 9 January 2007 (UTC)

Ah HAH! try this for Hargreaves and this for Olney. If that doesn't work, I give up. I'm changing the links in the article. delldot | talk 18:34, 9 January 2007 (UTC)

If you hear Olney's lesions being touted around at DXM, you'll know that it was cased by injection of MK-801 into rats, and as a NMDA antagonist, it was assumed the all of the antagonists could cause lesions. --68.45.219.63 (talk) 19:03, 6 March 2008 (UTC)

[edit] Residual deficits in thinking

This statement is unsourced. What does it really mean? Permanent? Miserlou (talk) 21:48, 27 November 2007 (UTC)