Dimethylmercury

From Wikipedia, the free encyclopedia

Dimethylmercury
IUPAC name dimethylmercury
Identifiers
CAS number [593-74-8]
Properties
Molecular formula C2H6Hg
Molar mass 230.659 g/mol
Appearance Colorless liquid
Density 2.96 g/ml, liquid
Melting point

-43 °C
Boiling point

87 - 97 °C
Solubility in water Insoluble
Viscosity  ? cP at ?°C
Hazards
R-phrases R26, R27, R28,
R33, R50, R53
S-phrases S13, S28, S36, S45,
S60, S61
Flash point N/A
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Dimethylmercury ((CH3)2Hg) is a flammable, colorless liquid, and one of the strongest known neurotoxins. It is described as having a slightly sweet smell, though inhaling enough fumes to notice this would involve significant exposure to the chemical. It is extremely dangerous, with absorption of doses as low as 0.001 mL being fatal. The high vapor pressure of the liquid means that any spillage will result in dangerous levels of exposure to the fumes for those nearby. The molecule adopts a linear structure.

Dimethylmercury crosses the blood-brain barrier easily, probably due to formation of a complex with cysteine. It is eliminated from the organism very slowly, therefore it has tendency to bioaccumulate. The symptoms of poisoning may appear when it is too late for effective treatment.

Dimethylmercury passes through latex, PVC, butyl, and neoprene rapidly (within seconds), and is absorbed through the skin. Therefore, most laboratory gloves do not provide adequate protection from it, and the only safe precaution is to handle dimethylmercury while wearing highly resistant laminated gloves underneath long-cuffed neoprene or other heavy-duty gloves. A long face shield and work under a fume hood are also indicated.

The toxicity of dimethylmercury was highlighted when a well-known chemist, Karen Wetterhahn, died after spilling a few drops of this compound on her latex-gloved hand.

Contents

[edit] Use

Dimethylmercury is most often used in toxicology experiments as a fixed point of reference due to its extreme toxicity. It has also been used to calibrate NMR instruments for detection of mercury, although less toxic mercury salts are preferred.[1][2]

[edit] See also

[edit] References

  1. ^ Chris Singer (10 Mar 1998). 199Hg Standards.
  2. ^ Roy Hoffman (21 Feb 2007). Mercury NMR.

[edit] External links