Talk:Dihydrotestosterone

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Does green tea lower DHT? the paragraph on this seems conflicting


"DHT is thought to be approximately 30 times more potent than testosterone." For doing ... what? In all cases? Isidore 21:19, 8 Jun 2005 (UTC)

Well, DHT has more affinity to the androgen receptor, and is therefore more potent in every aspect. JFW | T@lk 22:31, 8 Jun 2005 (UTC)

Contents

[edit] DHT and Muscle Growth

"DHT has been shown to be deactivated in skeletal muscle through the actions of 3-alpha hydroxysteroid dehydrogenase and therefore does not have a significant effect on muscle hypertrophy." ....

"Women with increased levels of DHT may develop certain androgynous male secondary sex characteristics, including hair above the lip, a deepened voice, and increased muscular growth."

Here are two clearly contradictory sentences in the same article. Which one is correct ?? Which one do we remove or modify ??

Inhibiting the 3-alpha hydroxysteroid dehydrogenase enzyme basically lets us tap into DHTs muscle there are certain ways to do it.

What is the normal range? I have two values one at 30-80 ng/dL and the other at 112-995 pg/mL which is 1120-9950 ng/dL. Both can not be correct! Also what is the lowest value a lab can measure? For someone with prostrate cancer and on hormones this is an important question.

I think the muscle growth in women would be due to increased testosterone, which is then converted into DHT... so it is a correlation and not causation. I rephrased the line, but change it back if it works differently in women for some reason.

[edit] "overproduction"

The part about drugs being used to treat DHT overproduction was removed as it's misleading. Normal DHT production causes most of the problems, except in women.

[edit] andrdogenic potential of DHT / testosterone

This page says DHT is about 30 times more potent than testosterone, but the article testosterone says DHT is 2.5 times more potent than testosterone. I suppose it is all apprioximations, but it looks confusing. / Habj 23:19, 7 November 2005 (UTC)


Given that DHT deficiency has been associated with Alzheimer's Disease, is it possible that finasteride (Proscar and Propecia) can result in memory impairment and other auto immune diseases such as heart disease, thyriod disease, skin cancer, arthritus etc.


I've been taking it for about 6 years and have noted a decrement in memory. I'm in my late 30's and wonder if this is just natural aging (I'm relatively young for significant memory impairment) or if it could be due to this medication.

reducing levels of DHT will in the long run, cause auto immune disease such as Alzheimers,

Alzheimer's is not an immune disease. Nor is heart disease or cancer, at least not primarily. There is no evidence whatsoever that finasteride causes any clinical immune dysfunction. Th1/Th2 balance is a laboratory measure[1]. Please do not insert original research on Wikipedia. JFW | T@lk 16:00, 7 June 2006 (UTC)

DHT also causes hirsutism and/or PCOS in Women.

Causes PCOS? Or are elevated levels just associated with PCOS? --Ryan Wise 10:30, 1 August 2006 (UTC)

[edit] 5α-reductase and aeromatase promotors

Everyone is talking about 5α-reductase and aeromatase inhibitors. But Can somebody tell me about the drugs which can promote their activity —The preceding unsigned comment was added by 202.141.36.72 (talk) 06:14, 16 March 2007 (UTC).


you can't promote an enzymes activity , you can only take more of it via injection or pills , (Yes there are pills like this on the market) if your interested in it' muscle growth potential you might want an 3-alpha hydroxysteroid dehydrogenase inhibitor.

[edit] systematic name

Isn't the systematic name 5-alpha-androstan-3-one-17-beta-ol? Jack Daw 17:08, 26 August 2007 (UTC)

[edit] normal range or estimates for dht?

there's no normal ranges on here for dht, does anyone know what a normal dht range should be? Nemo.shark (talk) 03:43, 5 January 2008 (UTC)

[edit] DHT receptor question

DHT and Testosterone are often referred to throughout scientific literature in the same breath. They are both androgens, and likewise, tend to affect the same target tissues (though sometimes in very different ways). I'm curious, though, about the hormone receptors on those target tissues.

I've read several articles which make mention of "androgen receptors" or "androgen sensitivity", but I've yet to find something which makes clear if DHT and Testosterone utilize the same receptors on target tissues, or different ones. Does DHT bind to the exact same type of receptor as testosterone? And if so, how do drugs like finasteride regulate one, without impacting the other?

Pine (talk) 23:20, 9 January 2008 (UTC)

[edit] DHT and Semen

This is a rather strange topic that came up today while I was having a discussion with co-workers during our lunch break: According to the article, DHT is present in the testes, thus assumed to be a byproduct or semen (or semen is a byproduct of DHT). Does that mean (is there any scientific or at least some sort of experiment proving) that if a male individual ingests semen over a period of time that androgenic alopecia, or male pattern baldness, is more prone to occur? In other words, if a male ingests his semen on a regular basis, would he begin to show signs of male-pattern baldness over time? --SetandSpike (talk) 05:26, 15 January 2008 (UTC)

eew. —Preceding unsigned comment added by 133.62.200.220 (talk) 05:13, 2 April 2008 (UTC)