Diffuse neuro-endocrine system

From Wikipedia, the free encyclopedia

This article may require cleanup to meet Wikipedia's quality standards. Please improve this article if you can. (January 2008)

This article or section needs to be wikified to meet Wikipedia's quality standards. Please help improve this article with relevant internal links. (January 2008)

This article does not cite any references or sources. (January 2008) Please help improve this article by adding citations to reliable sources. Unverifiable material may be challenged and removed.

Diffuse Neuro-Endocrine System (DNES) consists of cells from the central nervous system (CNS), Peripheral nervous system (PNS) and nearly all organs with the common phenotype: The ability to produce biological active Amines or Peptides which act like Neurotransmitters (NT), Hormones or Paracrine regulators.

It regroups the old APUD system which stated that all these cells originated from the neural tube.

The DNES states that only certain kind of cells originate from this neural tube and that others are from endodermal or endodermal origine as well as that the synthesis of peptides is more present than the synthesis of amines.

[edit] Groups within the DNES

(1) The Neural Type  : which include

• Adrenal medulla
• Para ganglia

(2) The Epithelial type : which include

(separate endocrine gland, or parts thereof)

• Adenohypophysis
• Islets of Langerhans
• parathyroid gland
• Pineal gland

(unicellular glands incorporated in other epithelial cells)

• GI Tract
• Lever
• Merkel cells of the Skin
• Parafollicular cell of the Thyroid gland
• Mammary glands
• urogenital system (male and female)
• Respiratory system

[edit] References

• DNES