Diablo homolog

From Wikipedia, the free encyclopedia

Diablo homolog (Drosophila)

PDB rendering based on 1few.

Available structures: 1few, 1g73

Identifiers

Symbol(s)

DIABLO; DIABLO-S; FLJ10537; FLJ25049; SMAC; SMAC3

External IDs

OMIM: 605219 MGI: 1913843 HomoloGene: 10532

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cytoplasm • mitochondrion
Biological Process:	• apoptosis • induction of apoptosis • induction of apoptosis via death domain receptors • induction of apoptosis by oxidative stress • caspase activation via cytochrome c

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019887 (mRNA)
NP_063940 (protein)

NM_023232 (mRNA)
NP_075721 (protein)

Location

Chr 12: 121.26 - 121.28 Mb

Chr 5: 123.77 - 123.78 Mb

Pubmed search

[1]

[2]

Diablo homolog (Drosophila), also known as DIABLO, is a human gene.^[1]

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.^[2]

[edit] References

[edit] Further reading

Shi Y (2001). "A structural view of mitochondria-mediated apoptosis.". Nat. Struct. Biol. 8 (5): 394–401. doi:10.1038/87548. PMID 11323712.
Anguiano-Hernandez YM, Chartier A, Huerta S (2007). "Smac/DIABLO and colon cancer.". Anti-cancer agents in medicinal chemistry 7 (4): 467–73. PMID 17630921.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Du C, Fang M, Li Y, et al. (2000). "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.". Cell 102 (1): 33–42. PMID 10929711.
Verhagen AM, Ekert PG, Pakusch M, et al. (2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.". Cell 102 (1): 43–53. PMID 10929712.
Srinivasula SM, Datta P, Fan XJ, et al. (2000). "Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.". J. Biol. Chem. 275 (46): 36152–7. doi:10.1074/jbc.C000533200. PMID 10950947.
Chai J, Du C, Wu JW, et al. (2000). "Structural and biochemical basis of apoptotic activation by Smac/DIABLO.". Nature 406 (6798): 855–62. doi:10.1038/35022514. PMID 10972280.
Liu Z, Sun C, Olejniczak ET, et al. (2001). "Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.". Nature 408 (6815): 1004–8. doi:10.1038/35050006. PMID 11140637.
Wu G, Chai J, Suber TL, et al. (2001). "Structural basis of IAP recognition by Smac/DIABLO.". Nature 408 (6815): 1008–12. doi:10.1038/35050012. PMID 11140638.
Srinivasula SM, Hegde R, Saleh A, et al. (2001). "A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.". Nature 410 (6824): 112–6. doi:10.1038/35065125. PMID 11242052.
Huang Y, Park YC, Rich RL, et al. (2001). "Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.". Cell 104 (5): 781–90. PMID 11257231.
Roberts DL, Merrison W, MacFarlane M, Cohen GM (2001). "The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity.". J. Cell Biol. 153 (1): 221–8. PMID 11285287.
Verhagen AM, Silke J, Ekert PG, et al. (2002). "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.". J. Biol. Chem. 277 (1): 445–54. doi:10.1074/jbc.M109891200. PMID 11604410.
Adrain C, Creagh EM, Martin SJ (2002). "Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.". EMBO J. 20 (23): 6627–36. doi:10.1093/emboj/20.23.6627. PMID 11726499.
Sun XM, Bratton SB, Butterworth M, et al. (2002). "Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein.". J. Biol. Chem. 277 (13): 11345–51. doi:10.1074/jbc.M109893200. PMID 11801595.
Vucic D, Deshayes K, Ackerly H, et al. (2002). "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).". J. Biol. Chem. 277 (14): 12275–9. doi:10.1074/jbc.M112045200. PMID 11801603.