dGTPase

From Wikipedia, the free encyclopedia

In enzymology, a dGTPase (EC 3.1.5.1) is an enzyme that catalyzes the chemical reaction

dGTP + H₂O deoxyguanosine + triphosphate

Thus, the two substrates of this enzyme are dGTP and H₂O, whereas its two products are deoxyguanosine and triphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on triphosphoric monoester bonds. The systematic name of this enzyme class is dGTP triphosphohydrolase. Other names in common use include deoxy-GTPase, deoxyguanosine 5-triphosphate triphosphohydrolase, deoxyguanosine triphosphatase, and deoxyguanosine triphosphate triphosphohydrolase. This enzyme participates in purine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1HA3, 2C77, 2C78, and 2DQB.

[edit] References

• IUBMB entry for 3.1.5.1
• BRENDA references for 3.1.5.1 (Recommended.)
• PubMed references for 3.1.5.1
• PubMed Central references for 3.1.5.1
• Google Scholar references for 3.1.5.1
• KORNBERG SR, LEHMAN IR, BESSMAN MJ, SIMMS ES, KORNBERG A (1958). "Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate". J. Biol. Chem. 233: 159–62. PMID 13563461. 

[edit] External links

The CAS registry number for this enzyme class is 9025-63-2.

• IUBMB entry for 3.1.5.1

• KEGG entry for 3.1.5.1

• BRENDA entry for 3.1.5.1

• NiceZyme view of 3.1.5.1

• EC2PDB: PDB structures for 3.1.5.1

• PRIAM entry for 3.1.5.1

• PUMA2 entry for 3.1.5.1

• IntEnz: Integrated Enzyme entry for 3.1.5.1

• MetaCyc entry for 3.1.5.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008832: dGTPase

• AMIGO entry for GO code 0008832: dGTPase