Talk:Dexmethylphenidate
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[edit] History
In 1948, Joseph Conrad E. discovered that by swimming, his leg edema decreased. He felt that this was due to the unifrom pressure created by water. The Ace stocking he used to wear, was inappropriate as it created tight and loose bands and worsened the ailment, Based on this principle, he created first customized pressure garment and later the Pneumatic Compression Machine.
Pumps were found useful to treat [Lymphoedema], [Venous Oedema] and other conditions where the swelling is due to a local lymph flow problem. They are more effective in ["http://www.lymph-india.org" Filariasis] and Post inflammatory Oedema. In these the lymphatics are present but dilated. They are less effective for post mastectomy and primary oedemas where the lyphatics are absent or have been physically destroyed.
Two types of pumps are available: Monolocular or Flowtron type. These have a single chamber with uniform pressure generated. Sequential, where multiple chambers are present - between 3 - 12 in various models. The most famous of these is the Lymphapress.
The former are slower to act but have less complications. The latter are recommended only for mild disease as the complications of Thigh and genital swelling, Congestive failure and fluid overload were found unacceptable.
Removed by: --Patik 04:19, July 16, 2005 (UTC)
[edit] more information
can someone who is qualified track down more information on this subject? More and more doctors are prescribing this drug every day.
- What sort of information would you like to see? -Muugokszhiion 22:59, 9 January 2007 (UTC)
- Would the information I have added be what you are looking for? I focused mainly on FocalinXR capsules instead of Focalin tablets. Takaian 12:04, 3 April 2007 (UTC)
[edit] Variability of side effects
The article states that dexmethylphenidate's side effects are "highly variable among users". A comparison with normal methylphenidate is needed here, since the exclusion of the inactive isomer should generally lead to more consistency of side effects among users.
[edit] Blatantly Biased
This article reads like an advertisement. No, really. I feel like if I was a parent Id get a strong urge to get this prescribed to my unruly kid. Did the pharmaceutical company write this itself or what?
~Yeah I feel the same way. It is very VERY biased. Someone needs to look into this.
- Agreed, this article definitely took a turn for the worse. Reads like a PDR with an agenda right now. -Muugokszhiion 19:50, 17 May 2007 (UTC)
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- I think the right way to handle this would be to create a separate page for Focalin, following the conventions for other drugs. I'll start it off. Inhumandecency 19:22, 27 June 2007 (UTC)
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[edit] "Reception" section
I hate to delete someone else's work outright, but the "reception" section seemed to be entirely based on the page from minreference.com, a natural health site that was making lots of vague and unfounded claims. I judged that the most significant parts were about the side effects, and that topic is already covered. Inhumandecency 08:03, 28 June 2007 (UTC)
- Also, mindreference.com appears to be shilling for Serenity, a non-prescription lithium drug! Inhumandecency 08:07, 28 June 2007 (UTC)
[edit] Wrong stereoisomer
Apologies if I have gone about this wrong, or broken some etiquette rule, but I thought I would point out that the molecule shown as dexmethylphenidate, is in fact the (S,S) isomer, which is the enantiomer of the actual drug, which is properly named as the (R,R) isomer. Also, the ball-and-stick (3D) model is the wrong isomer. I don't know how to edit Wikipedia, and I haven't the time to learn right at the moment, but I have drawn and posted the proper isomer at this address:
http://www.thisisruss.org/chemistry/dexmethylphenidate.gif
Anyone who has the time and knowhow to change the entry is welcome to use this image (preferably download and repost, rather than hotlink). I do not need credit, or care about rights to the image. Unfortunately, I haven't got access to software to draw the 3D model, so someone else will have to redraw that one, but in the meantime, perhaps the 3D image ought to be taken down, or a note indicating that the it is the enantiomer would be appropriate.
Cheers, Russ Viirre, Assistant Prrofessor, Dept. of Chemistry and Biology Ryerson University —Preceding unsigned comment added by 141.117.15.83 (talk) 15:47, 19 September 2007 (UTC)
- Yes, that was rather levmethylphenidate. I changed the 2D image to proper one and removed the 3D until someone draws the (R,R) for that one.
User:Angsaar 20:30, 13 October 2007
