Dexetimide


Dexetimide
Systematic (IUPAC) name
3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione
Identifiers
CAS number	21888-98-2
ATC code	N04AA08
PubChem	21847
Chemical data
Formula	C₂₃H₂₆N₂O₂
Mol. mass	362.465 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Dexetimide is a piperidine anticholinergic. It is a muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Dexetimide was discovered at Janssen Pharmaceutica in 1968.

[edit] References

Dom R, Van Lommel R, Baro F., A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent, Acta Psychiatrica Scandinavica 1971;47(4):399-410.
Huygens H, Vereecken JL, Tanghe A., Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action, Psychiatr Neurol Neurochir. 1973 Jul-Aug;76(4):251-9.

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v • d • e Anti-parkinson drugs: anticholinergic agents (N04A)

Tertiary amines	Trihexyphenidyl - Biperiden - Metixene - Procyclidine - Profenamine - Dexetimide - Phenglutarimide - Mazaticol - Bornaprine - Tropatepine

Ethers chemically close to antihistamines	Etanautine - Orphenadrine

Ethers of tropine or tropine derivatives	Benzatropine - Etybenzatropine