Deoxyribonuclease II

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deoxyribonuclease II alpha
Identifiers
Symbol	DNASE2
Alt. Symbols	DNASE2A, DRN2, DNL, DNL2
Entrez	1777
HUGO	2960
OMIM	126350
RefSeq	NM_001375
UniProt	O00115
Other data
EC number	3.1.22.1
Locus	Chr. 19 p13.2

deoxyribonuclease II beta
Identifiers
Symbol	DNASE2B
Entrez	58511
HUGO	28875
OMIM	608057
RefSeq	NM_021233
UniProt	Q8WZ79
Other data
EC number	3.1.22.1
Locus	Chr. 1 p22.3

Deoxyribonuclease II, or Acid DNase, hydrolyzes deoxyribonucleotide linkages in native and denatured DNA yielding products with 3'-phosphates. As the name implies, it is more effective at acid pHs.

There are several known DNases II, including:

• DNase II alpha (usually just called DNase II)
• DNase II beta (also called DLAD, or DNase II-Like Acid DNase)

[edit] External links

• MeSH deoxyribonuclease+II

v • d • e Hydrolase, esterase: nucleases (EC 3.1.11 - 3.1.31) - includes deoxyribonuclease and ribonuclease 3.1.11-16: Exonuclease Exodeoxyribonuclease (RecBCD) Exoribonuclease (Oligonucleotidase) 3.1.21-31: Endonuclease Endodeoxyribonuclease (Deoxyribonuclease I, Deoxyribonuclease II, Deoxyribonuclease IV, Restriction enzyme, UvrABC endonuclease) Endoribonuclease (RNase III, RNase H, RNase P, RNase A, RNase T1, RNA-induced silencing complex) either deoxy- or ribo- (Aspergillus nuclease S1, Micrococcal nuclease)