Deoxycytidylate C-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a deoxycytidylate C-methyltransferase (EC 2.1.1.54) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + dCMP dihydrofolate + deoxy-5-methylcytidylate

Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolic acid and dCMP, whereas its two products are dihydrofolic acid and deoxy-5-methylcytidylic acid.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:dCMP C-methyltransferase. Other names in common use include deoxycytidylate methyltransferase, and dCMP methyltransferase.

[edit] References

• IUBMB entry for 2.1.1.54
• BRENDA references for 2.1.1.54 (Recommended.)
• PubMed references for 2.1.1.54
• PubMed Central references for 2.1.1.54
• Google Scholar references for 2.1.1.54
• Kuo TT, Tu J (1976). "Enzymatic synthesis of deoxy-5-methyl-cytidylic acid replacing deoxycytidylic acid in Xanthomonas oryzae phage Xp12DNA". Nature. 263: 615. PMID 980110. 

[edit] External links

The CAS registry number for this enzyme class is 61970-01-2.

• IUBMB entry for 2.1.1.54

• KEGG entry for 2.1.1.54

• BRENDA entry for 2.1.1.54

• NiceZyme view of 2.1.1.54

• EC2PDB: PDB structures for 2.1.1.54

• PRIAM entry for 2.1.1.54

• PUMA2 entry for 2.1.1.54

• IntEnz: Integrated Enzyme entry for 2.1.1.54

• MetaCyc entry for 2.1.1.54

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050003: deoxycytidylate C-methyltransferase

• AMIGO entry for GO code 0050003: deoxycytidylate C-methyltransferase