Demethylmacrocin O-methyltransferase

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In enzymology, a demethylmacrocin O-methyltransferase (EC 2.1.1.102) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + demethylmacrocin $\rightleftharpoons$ S-adenosyl-L-homocysteine + macrocin

Thus, the two substrates of this enzyme are S-adenosyl methionine and demethylmacrocin, whereas its two products are S-adenosylhomocysteine and macrocin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:demethylmacrocin 2"'-O-methyltransferase. This enzyme is also called demethylmacrocin methyltransferase. This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides.

[edit] References

IUBMB entry for 2.1.1.102
BRENDA references for 2.1.1.102 (Recommended.)
PubMed references for 2.1.1.102
PubMed Central references for 2.1.1.102
Google Scholar references for 2.1.1.102
Kreuzman AJ, Turner JR, Yeh WK (1988). "Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis Substrate specificity, enzyme inhibition, and kinetic mechanism". J. Biol. Chem. 263: 15626–33. PMID 3170602.