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E. I. du Pont de Nemours and Company was founded in July 1802 as a gun powder mill by Eleuthère Irénée du Pont on Brandywine Creek, near Wilmington, Delaware, USA. DuPont is currently the world's second largest chemical company (behind BASF) in terms of market capitalization and fourth (behind BASF, Dow Chemical and Ineos) in revenue. It is also a component of the Dow Jones Industrial Average.

In the twentieth century, DuPont led the polymer revolution by developing many highly successful materials such as Vespel, neoprene, nylon, Corian, Teflon, Mylar, Kevlar, M5 fiber, Nomex, Tyvek and Lycra. DuPont has also been significantly involved in the refrigerant industry, developing and producing the Freon (CFCs) series and later, more environmentally-friendly refrigerants. In the paint and pigment industry, it has created synthetic pigments and paints, such as ChromaFlair.

DuPont is often successful in popularizing the brands of its material products such that their trademark names become more commonly used than the generic or chemical word(s) for the material itself. One example is “neoprene”, which was intended originally to be a trademark but quickly came into common usage.