Delta-like 1

From Wikipedia, the free encyclopedia

Delta-like 1 (Drosophila)

Identifiers

DLL1; DELTA1; Delta

External IDs

OMIM: 606582 MGI: 104659 HomoloGene: 4104

Gene ontology
Molecular Function:	• Notch binding • calcium ion binding • protein binding
Cellular Component:	• extracellular region • plasma membrane • integral to plasma membrane • cytoplasmic vesicle
Biological Process:	• in utero embryonic development • cell fate determination • somite specification • cell communication • Notch signaling pathway • multicellular organismal development • determination of left/right symmetry • compartment specification • nervous system development • organ morphogenesis • auditory receptor cell fate commitment • hemopoiesis • cell differentiation • regulation of cell adhesion • inner ear morphogenesis • odontogenesis (sensu Vertebrata) • negative regulation of cell differentiation • negative regulation of auditory receptor cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005618 (mRNA)
NP_005609 (protein)

NM_007865 (mRNA)
NP_031891 (protein)

Location

Chr 6: 170.43 - 170.44 Mb

Chr 17: 15.07 - 15.08 Mb

Pubmed search

[1]

[2]

Delta-like 1 (Drosophila), also known as DLL1, is a human gene.^[1]

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.^[1]

[edit] References

^ ^a ^b Entrez Gene: DLL1 delta-like 1 (Drosophila).

[edit] Further reading

Watt FM (2002). "The stem cell compartment in human interfollicular epidermis.". J. Dermatol. Sci. 28 (3): 173–80. PMID 11912004.
Lewis AK, Frantz GD, Carpenter DA, et al. (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.". Mech. Dev. 78 (1-2): 159–63. PMID 9858718.
Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation.". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480.
Gray GE, Mann RS, Mitsiadis E, et al. (1999). "Human ligands of the Notch receptor.". Am. J. Pathol. 154 (3): 785–94. PMID 10079256.
Beckers J, Clark A, Wünsch K, et al. (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development.". Mech. Dev. 84 (1-2): 165–8. PMID 10473134.
Morrison A, Hodgetts C, Gossler A, et al. (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear.". Mech. Dev. 84 (1-2): 169–72. PMID 10473135.
Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells.". Blood 95 (5): 1616–25. PMID 10688816.
Shimizu K, Chiba S, Hosoya N, et al. (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.". Mol. Cell. Biol. 20 (18): 6913–22. PMID 10958687.
Shimizu K, Chiba S, Saito T, et al. (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
Jaleco AC, Neves H, Hooijberg E, et al. (2001). "Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation.". J. Exp. Med. 194 (7): 991–1002. PMID 11581320.
Shimizu K, Chiba S, Saito T, et al. (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMID 11823422.
Panin VM, Shao L, Lei L, et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe.". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
Sakamoto K, Yamaguchi S, Ando R, et al. (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells.". J. Clin. Invest. 110 (8): 1165–74. PMID 12393852.
Karlström H, Beatus P, Dannaeus K, et al. (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMID 12482954.
Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines.". Int. J. Oncol. 22 (5): 1073–9. PMID 12684674.
Six E, Ndiaye D, Laabi Y, et al. (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. doi:10.1073/pnas.1230693100. PMID 12794186.
LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.