DEAD box

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The DEAD box is named for the consensus sequence of amino acids in the Walker B motif. This motif is responsible for binding nucleoside triphosphates such as ATP. DEAD-box proteins, among which are conserved nine domains, can be found in both prokaryotes and eukaryotes, but not all. Many organisms, including humans, contain DEAD-box helicases, which are involved in RNA metabolism.

[edit] See also

  • DEAD-box helicase
  • DEAH-box helicase
  • Ski 2 helicase
  • Walker A motif
  • RNA helicase

[edit] References

  • Heung, Lena J; Maurizio Del Poeta (2005). "Unlocking the DEAD-box: a key to cryptococcal virulence?". JOURNAL OF CLINICAL INVESTIGATION 115 (3): 593–595. USA: ROCKEFELLER UNIVERSITY PRESS. doi:10.1172/JCI200524508. ISSN 0021-9738.