DBF4

From Wikipedia, the free encyclopedia

DBF4 homolog (S. cerevisiae)

Identifiers

DBF4; ASK; DBF4A

External IDs

OMIM: 604281 MGI: 1351328 HomoloGene: 40892

Gene ontology
Molecular Function:	• nucleic acid binding • protein binding • enzyme activator activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• regulation of progression through cell cycle • G1/S transition of mitotic cell cycle • DNA replication • cell cycle

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006716 (mRNA)
NP_006707 (protein)

NM_013726 (mRNA)
NP_038754 (protein)

Location

n/a

Chr 5: 8.4 - 8.43 Mb

Pubmed search

[1]

[2]

DBF4 homolog (S. cerevisiae), also known as DBF4, is a human gene.^[1]

[edit] References

^ Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae).

[edit] Further reading

Kumagai H, Sato N, Yamada M, et al. (1999). "A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.". Mol. Cell. Biol. 19 (7): 5083-95. PMID 10373557.
Lepke M, Pütter V, Staib C, et al. (1999). "Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes.". Mol. Gen. Genet. 262 (2): 220-9. PMID 10517317.
Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.". EMBO J. 18 (20): 5703-13. doi:10.1093/emboj/18.20.5703. PMID 10523313.
Yamada M, Sato N, Taniyama C, et al. (2002). "A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase.". J. Biol. Chem. 277 (31): 27668-81. doi:10.1074/jbc.M202884200. PMID 12015319.
Wu X, Lee H (2002). "Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements.". Oncogene 21 (51): 7786-96. doi:10.1038/sj.onc.1205914. PMID 12420215.
Duncker BP, Shimada K, Tsai-Pflugfelder M, et al. (2003). "An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing.". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16087-92. doi:10.1073/pnas.252093999. PMID 12441400.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Costanzo V, Shechter D, Lupardus PJ, et al. (2003). "An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.". Mol. Cell 11 (1): 203-13. PMID 12535533.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.". J. Mol. Biol. 327 (1): 111-28. PMID 12614612.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Schnepp RW, Hou Z, Wang H, et al. (2004). "Functional interaction between tumor suppressor menin and activator of S-phase kinase.". Cancer Res. 64 (18): 6791-6. doi:10.1158/0008-5472.CAN-04-0724. PMID 15374998.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gérard A, Koundrioukoff S, Ramillon V, et al. (2006). "The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen.". EMBO Rep. 7 (8): 817-23. doi:10.1038/sj.embor.7400750. PMID 16826239.
Tsuji T, Ficarro SB, Jiang W (2007). "Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.". Mol. Biol. Cell 17 (10): 4459-72. doi:10.1091/mbc.E06-03-0241. PMID 16899510.
Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, et al. (2007). "Cdc7-Dbf4 and the human S checkpoint response to UVC.". J. Biol. Chem. 282 (13): 9458-68. doi:10.1074/jbc.M611292200. PMID 17276990.