DAZAP2

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DAZ associated protein 2
Identifiers
Symbol(s) DAZAP2; KIAA0058; MGC14319; MGC766
External IDs OMIM: 607431 MGI: 1344344 HomoloGene: 8038
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9802 23994
Ensembl ENSG00000183283 ENSMUSG00000000346
Uniprot Q15038 Q3ULN7
Refseq NM_014764 (mRNA)
NP_055579 (protein)		 NM_011873 (mRNA)
NP_036003 (protein)
Location Chr 12: 49.92 - 49.92 Mb Chr 15: 100.44 - 100.45 Mb
Pubmed search [1] [2]

DAZ associated protein 2, also known as DAZAP2, is a human gene.[1]

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region and is deleted in many azoospermic and severely oligospermic men. It is thought that the Y chromosomal DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL.[1]

[edit] References

  1. ^ a b Entrez Gene: DAZAP2 DAZ associated protein 2.

[edit] Further reading

  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044. 
  • Tsui S, Dai T, Roettger S, et al. (2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.". Genomics 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750. 
  • Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP (2001). "Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates.". J. Biol. Chem. 276 (28): 26324–31. doi:10.1074/jbc.M101205200. PMID 11342538. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cohen-Barak O, Yi Z, Hagiwara N, et al. (2004). "Sox6 regulation of cardiac myocyte development.". Nucleic Acids Res. 31 (20): 5941–8. PMID 14530442. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Shi Y, Luo S, Peng J, et al. (2005). "The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma.". Genomics Proteomics Bioinformatics 2 (1): 47–54. PMID 15629043. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Shi YW, Shen R, Ren W, et al. (2007). "Molecular features and expression of DAZAP2 in human multiple myeloma.". Chin. Med. J. 120 (19): 1659–65. PMID 17935665. 
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