DAP (gene)

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Death-associated protein
Identifiers
Symbol(s) DAP; MGC99796
External IDs OMIM: 600954 MGI: 1918190 HomoloGene: 3235
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1611 223453
Ensembl ENSG00000112977 ENSMUSG00000039168
Uniprot P51397 Q3U706
Refseq NM_004394 (mRNA)
NP_004385 (protein)		 NM_146057 (mRNA)
NP_666169 (protein)
Location Chr 5: 10.73 - 10.81 Mb Chr 15: 31.17 - 31.22 Mb
Pubmed search [1] [2]

Death-associated protein, also known as DAP, is a human gene.[1]

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.[1]

[edit] References

  1. ^ a b Entrez Gene: DAP death-associated protein.

[edit] Further reading

  • Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.". Oncogene 17 (25): 3331–40. doi:10.1038/sj.onc.1202588. PMID 9916995. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins.". J. Proteome Res. 5 (4): 925–34. doi:10.1021/pr050415p. PMID 16602700. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Feinstein E, Druck T, Kastury K, et al. (1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively.". Genomics 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096. 
  • Deiss LP, Feinstein E, Berissi H, et al. (1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.". Genes Dev. 9 (1): 15–30. PMID 7828849. 
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