DAPK1

From Wikipedia, the free encyclopedia

Death-associated protein kinase 1

PDB rendering based on 1ig1.

Available structures: 1ig1, 1jkk, 1jkl, 1jks, 1jkt, 1p4f, 1wvw, 1wvx, 1wvy

Identifiers

Symbol(s)

DAPK1; DAPK; DKFZp781I035

External IDs

OMIM: 600831 MGI: 1916885 HomoloGene: 3626

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • calmodulin-dependent protein kinase activity • calmodulin binding • ATP binding • kinase activity • transferase activity
Cellular Component:	• actin cytoskeleton
Biological Process:	• protein amino acid phosphorylation • apoptosis • signal transduction • protein kinase cascade • induction of apoptosis by extracellular signals

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004938 (mRNA)
NP_004929 (protein)

NM_029653 (mRNA)
NP_083929 (protein)

Location

Chr 9: 89.3 - 89.51 Mb

Chr 13: 60.61 - 60.77 Mb

Pubmed search

[1]

[2]

Death-associated protein kinase 1, also known as DAPK1, is a human gene.

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.^[1]

[edit] References

^ Entrez Gene: DAPK1 death-associated protein kinase 1.

[edit] Further reading

Deiss LP, Feinstein E, Berissi H, et al. (1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.". Genes Dev. 9 (1): 15–30. PMID 7828849.
Feinstein E, Druck T, Kastury K, et al. (1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively.". Genomics 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
Inbal B, Shani G, Cohen O, et al. (2000). "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.". Mol. Cell. Biol. 20 (3): 1044–54. PMID 10629061.
Jin Y, Blue EK, Dixon S, et al. (2001). "Identification of a new form of death-associated protein kinase that promotes cell survival.". J. Biol. Chem. 276 (43): 39667–78. doi:10.1074/jbc.M101886200. PMID 11485996.
Shohat G, Spivak-Kroizman T, Cohen O, et al. (2002). "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism.". J. Biol. Chem. 276 (50): 47460–7. doi:10.1074/jbc.M105133200. PMID 11579085.
Soria JC, Rodriguez M, Liu DD, et al. (2002). "Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers.". Cancer Res. 62 (2): 351–5. PMID 11809677.
Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.". Haematologica 87 (6): 569–77. PMID 12031912.
Hasegawa M, Nelson HH, Peters E, et al. (2002). "Patterns of gene promoter methylation in squamous cell cancer of the head and neck.". Oncogene 21 (27): 4231–6. doi:10.1038/sj.onc.1205528. PMID 12082610.
Jin Y, Blue EK, Dixon S, et al. (2003). "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK.". J. Biol. Chem. 277 (49): 46980–6. doi:10.1074/jbc.M208585200. PMID 12351649.
Wang WJ, Kuo JC, Yao CC, Chen RH (2002). "DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals.". J. Cell Biol. 159 (1): 169–79. doi:10.1083/jcb.200204050. PMID 12370243.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakatsuka S, Takakuwa T, Tomita Y, et al. (2003). "Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T- and natural killer (NK)/T-cell malignancies.". Cancer Sci. 94 (1): 87–91. PMID 12708480.
Tian JH, Das S, Sheng ZH (2003). "Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18.". J. Biol. Chem. 278 (28): 26265–74. doi:10.1074/jbc.M300492200. PMID 12730201.
Gonzalez-Gomez P, Bello MJ, Alonso ME, et al. (2004). "Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors.". Oncol. Rep. 10 (4): 1031–3. PMID 12792765.
Matsumoto H, Nagao M, Ogawa S, et al. (2003). "Prognostic significance of death-associated protein-kinase expression in hepatocellular carcinomas.". Anticancer Res. 23 (2B): 1333–41. PMID 12820391.
Henshall DC, Araki T, Schindler CK, et al. (2003). "Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.". J. Neurochem. 86 (5): 1260–70. PMID 12911633.
Voso MT, Scardocci A, Guidi F, et al. (2004). "Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes.". Blood 103 (2): 698–700. doi:10.1182/blood-2003-07-2249. PMID 14504087.
Jin Y, Gallagher PJ (2004). "Antisense depletion of death-associated protein kinase promotes apoptosis.". J. Biol. Chem. 278 (51): 51587–93. doi:10.1074/jbc.M309165200. PMID 14530257.
Kim WS, Son HJ, Park JO, et al. (2004). "Promoter methylation and down-regulation of DAPK is associated with gastric atrophy.". Int. J. Mol. Med. 12 (6): 827–30. PMID 14612952.
Bai T, Tanaka T, Yukawa K, et al. (2004). "Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells.". Oncol. Rep. 11 (3): 661–5. PMID 14767518.