Dantron

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Dantron
Systematic (IUPAC) name
1,8-dihydroxyanthracene-9,10-dione
Identifiers
CAS number	117-10-2
ATC code	A06AB03 A06AB53 A06AG03
PubChem	2950
Chemical data
Formula	C14H8O4
Mol. mass	240.211 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral, rectal (enema)

"Dantron" is also a trade name of ondansetron, an unrelated drug, in South Africa.

Dantron (also known as chrysazin) is an anthraquinone derivative, 1,8-dihydroxyanthraquinone, used in some countries as a stimulant laxative. In the USA it is considered to be a carcinogen,^[1] and is therefore not used. In the UK it is considered a possible carcinogen and so its licence is restricted to patients who already have a diagnosis of terminal cancer (i.e. it is mainly used in palliative care to counteract the constipating effects of opioids)

It has the notable side-effect of causing red-coloured urine.

Danthron was the British Approved Name, but it has now been changed to "dantron" in harmony with the recommended International Nonproprietary Name (rINN).

[edit] References

1. ^ Danthron substance profile at the National Toxicology Program website

v • d • e Laxatives (A06) Softeners, emollients Paraffin - Docusate sodium Contact laxatives Oxyphenisatine - Bisacodyl - Dantron - Phenolphthalein - Castor oil - Senna glycosides - Cascara - Sodium picosulfate - Bisoxatin Bulk producers Ispaghula - Ethulose - Sterculia - Linseed - Methylcellulose - Triticum - Polycarbophil calcium Osmotically acting laxatives Magnesium carbonate - Magnesium oxide - Magnesium peroxide - Magnesium sulfate - Lactulose - Lactitol - Sodium sulfate - Pentaerithrityl - Macrogol - Mannitol - Sodium phosphate - Sorbitol - Magnesium citrate - Sodium tartrate Enemas Sodium phosphate - Bisacodyl - Dantron - Glycerol - Oil - Sorbitol