D-serine ammonia-lyase

From Wikipedia, the free encyclopedia

In enzymology, a D-serine ammonia-lyase (EC 4.3.1.18) is an enzyme that catalyzes the chemical reaction

D-serine pyruvate + NH₃

Hence, this enzyme has one substrate, D-serine, and two products, pyruvate and NH₃.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is D-serine ammonia-lyase (pyruvate-forming). Other names in common use include D-hydroxyaminoacid dehydratase, D-serine dehydrase, D-hydroxy amino acid dehydratase, D-serine hydrolase, D-serine dehydratase (deaminating), D-serine deaminase, and D-serine hydro-lyase (deaminating). This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.3.1.18
• BRENDA references for 4.3.1.18 (Recommended.)
• PubMed references for 4.3.1.18
• PubMed Central references for 4.3.1.18
• Google Scholar references for 4.3.1.18
• Dupourque D, Newton WA, Snell EE (1966). "Purification and properties of D-serine dehydrase from Escherichia coli". J. Biol. Chem. 241: 1233–8. PMID 5327100. 
• METZLER DE, SNELL EE (1952). "Deamination of serine. II. D-Serine dehydrase, a vitamin B6 enzyme from Escherichia coli". J. Biol. Chem. 198: 363–73. PMID 12999751. 

[edit] External links

The CAS registry number for this enzyme class is 9015-88-7.

• IUBMB entry for 4.3.1.18

• KEGG entry for 4.3.1.18

• BRENDA entry for 4.3.1.18

• NiceZyme view of 4.3.1.18

• EC2PDB: PDB structures for 4.3.1.18

• PRIAM entry for 4.3.1.18

• PUMA2 entry for 4.3.1.18

• IntEnz: Integrated Enzyme entry for 4.3.1.18

• MetaCyc entry for 4.3.1.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008721: D-serine ammonia-lyase

• AMIGO entry for GO code 0008721: D-serine ammonia-lyase