D(-)-tartrate dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a D(-)-tartrate dehydratase (EC 4.2.1.81) is an enzyme that catalyzes the chemical reaction

(S,S)-tartrate $\rightleftharpoons$ oxaloacetate + H₂O

Hence, this enzyme has one substrate, (S,S)-tartrate, and two products, oxaloacetate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S,S)-tartrate hydro-lyase (oxaloacetate-forming). Other names in common use include D-tartrate dehydratase, and (S,S)-tartrate hydro-lyase. It has 2 cofactors: iron, and Manganese.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2DW6 and 2DW7.

[edit] References

IUBMB entry for 4.2.1.81
BRENDA references for 4.2.1.81 (Recommended.)
PubMed references for 4.2.1.81
PubMed Central references for 4.2.1.81
Google Scholar references for 4.2.1.81
Rode H, Giffhorn F (1982). "D-(--)-tartrate dehydratase of Rhodopseudomonas sphaeroides: purification, characterization, and application to enzymatic determination of D-(--)-tartrate". J. Bacteriol. 150: 1061–8. PMID 6978882.
Rode H, Giffhorn F (1982). "Ferrous- or cobalt ion-dependent D-(-)-tartrate dehydratase of pseudomonads: purification and properties". J. Bacteriol. 151: 1602–4. PMID 7107563.