Cytidylate cyclase

From Wikipedia, the free encyclopedia

In enzymology, a cytidylate cyclase (EC 4.6.1.6) is an enzyme that catalyzes the chemical reaction

CTP 3',5'-cyclic CMP + diphosphate

Hence, this enzyme has one substrate, CTP, and two products, 3',5'-cyclic CMP and diphosphate.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming). Other names in common use include 3',5'-cyclic-CMP synthase, cytidylyl cyclase, cytidyl cyclase, and CTP diphosphate-lyase (cyclizing).

[edit] References

• IUBMB entry for 4.6.1.6
• BRENDA references for 4.6.1.6 (Recommended.)
• PubMed references for 4.6.1.6
• PubMed Central references for 4.6.1.6
• Google Scholar references for 4.6.1.6
• Cech SY, Ignarro LJ (1978). "Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver". Biochem. Biophys. Res. Commun. 80: 119–25. doi:10.1016/0006-291X(78)91112-9. PMID 23778. 
• JH (1985). "3',5'-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian-tissues". Biochem. Soc. Trans. 13: 1134–1135. 

[edit] External links

The CAS registry number for this enzyme class is 65357-82-6.

• IUBMB entry for 4.6.1.6

• KEGG entry for 4.6.1.6

• BRENDA entry for 4.6.1.6

• NiceZyme view of 4.6.1.6

• EC2PDB: PDB structures for 4.6.1.6

• PRIAM entry for 4.6.1.6

• PUMA2 entry for 4.6.1.6

• IntEnz: Integrated Enzyme entry for 4.6.1.6

• MetaCyc entry for 4.6.1.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047805: cytidylate cyclase

• AMIGO entry for GO code 0047805: cytidylate cyclase