CYB5R4

From Wikipedia, the free encyclopedia

Cytochrome b5 reductase 4

Identifiers

CYB5R4; NCB5OR; RP4-676J13.1; dJ676J13.1

External IDs

OMIM: 608343 MGI: 2386848 HomoloGene: 69207

Gene ontology
Molecular Function:	• cytochrome-b5 reductase activity • iron ion binding • oxidoreductase activity • heme binding • transition metal ion binding
Cellular Component:	• cytoplasm
Biological Process:	• electron transport • sensory perception of chemical stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016230 (mRNA)
NP_057314 (protein)

NM_024195 (mRNA)
NP_077157 (protein)

Location

Chr 6: 84.63 - 84.73 Mb

Chr 9: 86.82 - 86.88 Mb

Pubmed search

[1]

[2]

Cytochrome b5 reductase 4, also known as CYB5R4, is a human gene.^[1]

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CYB5R4 cytochrome b5 reductase 4.

[edit] Further reading

Zhu H, Qiu H, Yoon HW, et al. (2000). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. PMID 10611283.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhu H, Larade K, Jackson TA, et al. (2004). "NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum.". J. Biol. Chem. 279 (29): 30316–25. doi:10.1074/jbc.M402664200. PMID 15131110.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Andersen G, Wegner L, Rose CS, et al. (2005). "Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.". Diabetes 53 (11): 2992–7. PMID 15504981.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.