CUL5

From Wikipedia, the free encyclopedia

Cullin 5

Identifiers

CUL5; VACM-1; VACM1

External IDs

OMIM: 601741 MGI: 1922967 HomoloGene: 2597

Gene ontology
Molecular Function:	• receptor activity • calcium channel activity • protein binding
Biological Process:	• regulation of progression through cell cycle • G1/S transition of mitotic cell cycle • ubiquitin cycle • cell cycle • cell cycle arrest • cell proliferation • negative regulation of cell proliferation • induction of apoptosis by intracellular signals

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003478 (mRNA)
NP_003469 (protein)

NM_027807 (mRNA)
NP_082083 (protein)

Location

Chr 11: 107.38 - 107.48 Mb

Chr 9: 53.38 - 53.42 Mb

Pubmed search

[1]

[2]

Cullin 5, also known as CUL5, is a human gene.^[1]

[edit] References

^ Entrez Gene: CUL5 cullin 5.

[edit] Further reading

Kipreos ET, Lander LE, Wing JP, et al. (1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.". Cell 85 (6): 829–39. PMID 8681378.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Byrd PJ, Stankovic T, McConville CM, et al. (1997). "Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23.". Genome Res. 7 (1): 71–5. PMID 9037604.
Stankovic T, Byrd PJ, Cooper PR, et al. (1997). "Construction of a transcription map around the gene for ataxia telangiectasia: identification of at least four novel genes.". Genomics 40 (2): 267–76. doi:10.1006/geno.1996.4595. PMID 9119394.
North WG, Fay MJ, Longo KA, Du J (1998). "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.". Cancer Res. 58 (9): 1866–71. PMID 9581826.
Burnatowska-Hledin M, Lazdins IB, Listenberger L, et al. (1999). "VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule.". Am. J. Physiol. 276 (2 Pt 2): F199–209. PMID 9950950.
Wada H, Yeh ET, Kamitani T (1999). "Identification of NEDD8-conjugation site in human cullin-2.". Biochem. Biophys. Res. Commun. 257 (1): 100–5. doi:10.1006/bbrc.1999.0339. PMID 10092517.
Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.". Mol. Cell 3 (4): 535–41. PMID 10230407.
Hori T, Osaka F, Chiba T, et al. (2000). "Covalent modification of all members of human cullin family proteins by NEDD8.". Oncogene 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293.
Burnatowska-Hledin M, Zhao P, Capps B, et al. (2000). "VACM-1, a cullin gene family member, regulates cellular signaling.". Am. J. Physiol., Cell Physiol. 279 (1): C266–73. PMID 10898738.
Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Burnatowska-Hledin , Zeneberg A, Roulo A, et al. (2001). "Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle.". Endothelium 8 (1): 49–63. PMID 11409851.
Harada JN, Shevchenko A, Shevchenko A, et al. (2002). "Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.". J. Virol. 76 (18): 9194–206. PMID 12186903.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu J, Furukawa M, Matsumoto T, Xiong Y (2003). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.". Mol. Cell 10 (6): 1511–8. PMID 12504025.
Van Dort C, Zhao P, Parmelee K, et al. (2004). "VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways.". Am. J. Physiol., Cell Physiol. 285 (6): C1386–96. doi:10.1152/ajpcell.00338.2002. PMID 12917106.
Yu X, Yu Y, Liu B, et al. (2003). "Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.". Science 302 (5647): 1056–60. doi:10.1126/science.1089591. PMID 14564014.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Burnatowska-Hledin MA, Kossoris JB, Van Dort CJ, et al. (2004). "T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene.". Biochem. Biophys. Res. Commun. 319 (3): 817–25. doi:10.1016/j.bbrc.2004.05.057. PMID 15184056.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.