CTNNA1

From Wikipedia, the free encyclopedia

Catenin (cadherin-associated protein), alpha 1, 102kDa

PDB rendering based on 1dov.

Available structures: 1dov, 1dow, 1h6g, 1l7c

Identifiers

Symbol(s)

CTNNA1; CAP102; FLJ36832

External IDs

OMIM: 116805 MGI: 88274 HomoloGene: 1433

Gene ontology
Molecular Function:	• structural molecule activity • protein binding • vinculin binding • cadherin binding
Cellular Component:	• actin cytoskeleton
Biological Process:	• cell adhesion • apical junction assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001903 (mRNA)
NP_001894 (protein)

NM_009818 (mRNA)
NP_033948 (protein)

Location

Chr 5: 138.12 - 138.3 Mb

Chr 18: 35.24 - 35.38 Mb

Pubmed search

[1]

[2]

Catenin (cadherin-associated protein), alpha 1, 102kDa, also known as CTNNA1, is a human gene.^[1]

[edit] See also

Alpha catenin

[edit] References

^ Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa.

[edit] Further reading

Nagafuchi A, Takeichi M, Tsukita S (1991). "The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.". Cell 65 (5): 849–57. PMID 1904011.
Herrenknecht K, Ozawa M, Eckerskorn C, et al. (1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9156–60. PMID 1924379.
Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.". J. Cell Biol. 130 (2): 461–71. PMID 7542250.
Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR (1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.". J. Biol. Chem. 270 (34): 20201–6. PMID 7650039.
Daniel JM, Reynolds AB (1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.". Mol. Cell. Biol. 15 (9): 4819–24. PMID 7651399.
Aberle H, Butz S, Stappert J, et al. (1995). "Assembly of the cadherin-catenin complex in vitro with recombinant proteins.". J. Cell. Sci. 107 ( Pt 12): 3655–63. PMID 7706414.
Knudsen KA, Soler AP, Johnson KR, Wheelock MJ (1995). "Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.". J. Cell Biol. 130 (1): 67–77. PMID 7790378.
Rimm DL, Kebriaei P, Morrow JS (1994). "Molecular cloning reveals alternative splice forms of human alpha(E)-catenin.". Biochem. Biophys. Res. Commun. 203 (3): 1691–9. doi:10.1006/bbrc.1994.2381. PMID 7945318.
Oyama T, Kanai Y, Ochiai A, et al. (1994). "A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.". Cancer Res. 54 (23): 6282–7. PMID 7954478.
McPherson JD, Morton RA, Ewing CM, et al. (1994). "Assignment of the human alpha-catenin gene (CTNNA1) to chromosome 5q21-q22.". Genomics 19 (1): 188–90. doi:10.1006/geno.1994.1042. PMID 8188230.
Su LK, Vogelstein B, Kinzler KW (1994). "Association of the APC tumor suppressor protein with catenins.". Science 262 (5140): 1734–7. PMID 8259519.
Oda T, Kanai Y, Shimoyama Y, et al. (1993). "Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line.". Biochem. Biophys. Res. Commun. 193 (3): 897–904. doi:10.1006/bbrc.1993.1710. PMID 8323564.
Furukawa Y, Nakatsuru S, Nagafuchi A, et al. (1993). "Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1).". Cytogenet. Cell Genet. 65 (1-2): 74–8. PMID 8404069.
Obama H, Ozawa M (1997). "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin).". J. Biol. Chem. 272 (17): 11017–20. PMID 9110993.
Linkels M, Bussemakers MJ, Nollet F, et al. (1997). "Molecular cloning of an alternative human alphaE-catenin cDNA.". Biochem. Biophys. Res. Commun. 237 (1): 177–81. doi:10.1006/bbrc.1997.7058. PMID 9266853.
Lewalle JM, Bajou K, Desreux J, et al. (1998). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro.". Exp. Cell Res. 237 (2): 347–56. doi:10.1006/excr.1997.3799. PMID 9434630.
Reuver SM, Garner CC (1998). "E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton.". J. Cell. Sci. 111 ( Pt 8): 1071–80. PMID 9512503.
Watabe-Uchida M, Uchida N, Imamura Y, et al. (1998). "alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.". J. Cell Biol. 142 (3): 847–57. PMID 9700171.
Roe S, Koslov ER, Rimm DL (1998). "A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity.". Cell Adhes. Commun. 5 (4): 283–96. PMID 9762469.
Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.". J. Biol. Chem. 274 (9): 5981–6. PMID 10026224.