Ctgf/hcs24 CAESAR

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ctgf/hcs24 CAESAR

Type:	Cis-reg;
2° structure:	Published; PubMed
Seed alignment:	Griffiths-Jones SR
Avg length:	78.9 nucleotides
Avg identity:	83%

ctgf/hcs24 CAESAR is the name given to the cis-acting RNA element identified in the 3' untranslated region (3'UTR) of the human connective tissue growth factor (ctgf) messenger RNA. ^[1]. This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).

The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised ^[1] and subsequently the minimal RNA element resposible for repression was identified^[2] . This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).

The 3'UTR of the ctgf/hcs24 gene is chicken has also been shown to be involved in repression of gene expression ^[3].

[edit] References

^ ^a ^b Kubota S, Hattori T, Nakanishi T, Takigawa M (1999). "Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene". FEBS Lett. 450 (1-2): 84–8. PMID 10350062.
^ Kubota S, Kondo S, Eguchi T, et al (2000). "Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions". Oncogene 19 (41): 4773–86. doi:10.1038/sj.onc.1203835. PMID 11032028.
^ Mukudai Y, Kubota S, Takigawa M (2003). "Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species". Biol. Chem. 384 (1): 1–9. PMID 12674494.