Crush syndrome
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notably myoglobin, potassium and phosphorus - that are the products of rhabdomyolysis (the breakdown of skeletal muscle damaged by ischemic conditions).
The specific action on the kidneys is not fully understood, but may be due in part to nephrotoxic metabolites of myoglobin.
[edit] Treatment
In view of the risk of crush syndrome, current recommendation to lay first-aiders (in the UK) is not to release victims of crush injury who have been trapped for over 15 minutes.
[edit] References
- Sever MS, Vanholder R, Lameire N (2006). "Management of crush-related injuries after disasters". N. Engl. J. Med. 354 (10): 1052–63. doi:. PMID 16525142.
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