CRMP1

From Wikipedia, the free encyclopedia

Collapsin response mediator protein 1

PDB rendering based on 1kcx.

Available structures: 1kcx

Identifiers

Symbol(s)

CRMP1; DPYSL1; DRP-1; DRP1

External IDs

OMIM: 602462 MGI: 107793 HomoloGene: 20347

Gene ontology
Molecular Function:	• dihydropyrimidinase activity • protein binding • hydrolase activity
Cellular Component:	• dendrite • cell soma
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001014809 (mRNA)
NP_001014809 (protein)

NM_007765 (mRNA)
NP_031791 (protein)

Location

Chr 4: 5.87 - 5.95 Mb

Chr 5: 37.53 - 37.58 Mb

Pubmed search

[1]

[2]

Collapsin response mediator protein 1, also known as CRMP1, is a human gene.^[1]

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: CRMP1 collapsin response mediator protein 1.

[edit] Further reading

Shih JY, Lee YC, Yang SC, et al. (2003). "Collapsin response mediator protein-1: a novel invasion-suppressor gene.". Clin. Exp. Metastasis 20 (1): 69–76. PMID 12650609.
Hamajima N, Matsuda K, Sakata S, et al. (1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.". Gene 180 (1-2): 157–63. PMID 8973361.
Torres R, Polymeropoulos MH (1999). "Genomic organization and localization of the human CRMP-1 gene.". DNA Res. 5 (6): 393–5. PMID 10048489.
Shih JY, Yang SC, Hong TM, et al. (2001). "Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells.". J. Natl. Cancer Inst. 93 (18): 1392–400. PMID 11562390.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology.". FEBS Lett. 532 (3): 445–9. PMID 12482610.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chang CC, Shih JY, Jeng YM, et al. (2004). "Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis.". J. Natl. Cancer Inst. 96 (5): 364–75. PMID 14996858.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sivakumaran TA, Lesperance MM (2005). "Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes.". Int. J. Mol. Med. 14 (5): 903–7. PMID 15492864.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Cole AR, Causeret F, Yadirgi G, et al. (2006). "Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.". J. Biol. Chem. 281 (24): 16591–8. doi:10.1074/jbc.M513344200. PMID 16611631.
Weidemann W, Stelzl U, Lisewski U, et al. (2007). "The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.". FEBS Lett. 580 (28-29): 6649–54. doi:10.1016/j.febslet.2006.11.015. PMID 17118363.