CRIM1

From Wikipedia, the free encyclopedia

Cysteine rich transmembrane BMP regulator 1 (chordin-like)

Identifiers

CRIM1; MGC138194; S52

External IDs

OMIM: 606189 MGI: 1354756 HomoloGene: 9510

Gene ontology
Molecular Function:	• cysteine-type endopeptidase activity • serine-type endopeptidase inhibitor activity • insulin-like growth factor receptor activity • insulin-like growth factor binding
Cellular Component:	• extracellular region • membrane fraction • membrane • integral to membrane
Biological Process:	• regulation of cell growth • proteolysis • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016441 (mRNA)
NP_057525 (protein)

NM_015800 (mRNA)
NP_056615 (protein)

Location

Chr 2: 36.44 - 36.63 Mb

Chr 17: 78.11 - 78.28 Mb

Pubmed search

[1]

[2]

Cysteine rich transmembrane BMP regulator 1 (chordin-like), also known as CRIM1, is a human gene.^[1]

Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like).

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Wilkinson L, Kolle G, Wen D, et al. (2003). "CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface.". J. Biol. Chem. 278 (36): 34181-8. doi:10.1074/jbc.M301247200. PMID 12805376.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Glienke J, Sturz A, Menrad A, Thierauch KH (2003). "CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo.". Mech. Dev. 119 (2): 165-75. PMID 12464430.
Georgas K, Bowles J, Yamada T, et al. (2001). "Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern.". Dev. Dyn. 219 (4): 582-7. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1072>3.0.CO;2-I. PMID 11084657.
Kolle G, Georgas K, Holmes GP, et al. (2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis.". Mech. Dev. 90 (2): 181-93. PMID 10642437.