CPNE6

From Wikipedia, the free encyclopedia

Copine VI (neuronal)

Identifiers

CPNE6; N-COPINE

External IDs

OMIM: 605688 MGI: 1334445 HomoloGene: 81815

Gene ontology
Molecular Function:	• phosphatidylserine binding • transporter activity • calcium ion binding
Cellular Component:	• membrane fraction • axon • dendrite
Biological Process:	• lipid metabolic process • synaptic transmission • nervous system development • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006032 (mRNA)
NP_006023 (protein)

NM_009947 (mRNA)
NP_034077 (protein)

Location

Chr 14: 23.61 - 23.62 Mb

Chr 14: 54.46 - 54.47 Mb

Pubmed search

[1]

[2]

Copine VI (neuronal), also known as CPNE6, is a human gene.^[1]

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.^[1]

[edit] References

^ ^a ^b Entrez Gene: CPNE6 copine VI (neuronal).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Nakayama T, Yaoi T, Yasui M, Kuwajima G (1998). "N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression.". FEBS Lett. 428 (1-2): 80-4. PMID 9645480.
Nakayama T, Yaoi T, Kuwajima G (1999). "Localization and subcellular distribution of N-copine in mouse brain.". J. Neurochem. 72 (1): 373-9. PMID 9886090.
Nakayama T, Yaoi T, Kuwajima G, et al. (1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma.". FEBS Lett. 453 (1-2): 77-80. PMID 10403379.
Caudell EG, Caudell JJ, Tang CH, et al. (2000). "Characterization of human copine III as a phosphoprotein with associated kinase activity.". Biochemistry 39 (42): 13034-43. PMID 11041869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.