CPNE1

From Wikipedia, the free encyclopedia

Copine I

Identifiers

CPNE1; CPN1; COPN1; MGC1142

External IDs

OMIM: 604205 MGI: 2386621 HomoloGene: 36501

Gene ontology
Molecular Function:	• phosphatidylserine binding • transporter activity • calcium-dependent phospholipid binding
Biological Process:	• lipid metabolic process • vesicle-mediated transport

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003915 (mRNA)
NP_003906 (protein)

NM_170588 (mRNA)
NP_733467 (protein)

Location

n/a

Chr 2: 155.76 - 155.77 Mb

Pubmed search

[1]

[2]

Copine I, also known as CPNE1, is a human gene.^[1]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: CPNE1 copine I.

[edit] Further reading

Creutz CE, Tomsig JL, Snyder SL, et al. (1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.". J. Biol. Chem. 273 (3): 1393-402. PMID 9430674.
Savino M, d'Apolito M, Centra M, et al. (1999). "Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3.". Genomics 61 (2): 219-26. doi:10.1006/geno.1999.5958. PMID 10534407.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048-54. doi:10.1074/jbc.M212632200. PMID 12522145.
Cowland JB, Carter D, Bjerregaard MD, et al. (2003). "Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils.". J. Leukoc. Biol. 74 (3): 379-88. PMID 12949241.
Tomsig JL, Sohma H, Creutz CE (2004). "Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine.". Biochem. J. 378 (Pt 3): 1089-94. doi:10.1042/BJ20031654. PMID 14674885.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63-72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.