CPEB1

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Cytoplasmic polyadenylation element binding protein 1
Identifiers
Symbol(s) CPEB1; CEBP; CPE-BP1; CPEB; FLJ13203; MGC34136; MGC60106
External IDs OMIM: 607342 MGI: 108442 HomoloGene: 7278
Orthologs
Human Mouse
Entrez 64506 12877
Ensembl n/a ENSMUSG00000025586
Uniprot n/a Q059Z2
Refseq NM_001079533 (mRNA)
NP_001073001 (protein)		 NM_007755 (mRNA)
NP_031781 (protein)
Location n/a Chr 7: 81.22 - 81.33 Mb
Pubmed search [1] [2]

Cytoplasmic polyadenylation element binding protein 1, also known as CPEB1, is a human gene.[1]

This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: CPEB1 cytoplasmic polyadenylation element binding protein 1.

[edit] Further reading

  • Mendez R, Richter JD (2001). "Translational control by CPEB: a means to the end.". Nat. Rev. Mol. Cell Biol. 2 (7): 521–9. doi:10.1038/35080081. PMID 11433366. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074. 
  • Welk JF, Charlesworth A, Smith GD, MacNicol AM (2001). "Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein.". Gene 263 (1-2): 113–20. PMID 11223249. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB.". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMID 12629046. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wilczynska A, Aigueperse C, Kress M, et al. (2005). "The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules.". J. Cell. Sci. 118 (Pt 5): 981–92. doi:10.1242/jcs.01692. PMID 15731006. 
  • Sasayama T, Marumoto T, Kunitoku N, et al. (2005). "Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1.". Genes Cells 10 (7): 627–38. doi:10.1111/j.1365-2443.2005.00870.x. PMID 15966895. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
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