CPD (gene)

From Wikipedia, the free encyclopedia

Carboxypeptidase D

Identifiers

External IDs

OMIM: 603102 MGI: 107265 HomoloGene: 999

Gene ontology
Molecular Function:	• carboxypeptidase activity • carboxypeptidase A activity • carboxypeptidase D activity • metallopeptidase activity • zinc ion binding • metallocarboxypeptidase D activity • metal ion binding
Cellular Component:	• membrane fraction • membrane • integral to membrane
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001304 (mRNA)
NP_001295 (protein)

XM_001001063 (mRNA)
XP_001001063 (protein)

Location

Chr 17: 25.73 - 25.82 Mb

Chr 11: 76.6 - 76.66 Mb

Pubmed search

[1]

[2]

Carboxypeptidase D, also known as CPD, is a human gene.^[1]

The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CPD carboxypeptidase D.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
McGwire GB, Tan F, Michel B, et al. (1997). "Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein.". Life Sci. 60 (10): 715–24. PMID 9064476.
Tan F, Rehli M, Krause SW, Skidgel RA (1997). "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains.". Biochem. J. 327 ( Pt 1): 81–7. PMID 9355738.
Varlamov O, Fricker LD (1998). "Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: localization to the trans-Golgi network and recycling from the cell surface.". J. Cell. Sci. 111 ( Pt 7): 877–85. PMID 9490632.
Riley DA, Tan F, Miletich DJ, Skidgel RA (1999). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1).". Genomics 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828.
Ishikawa T, Murakami K, Kido Y, et al. (1998). "Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme.". Gene 215 (2): 361–70. PMID 9714835.
Reznik SE, Salafia CM, Lage JM, Fricker LD (1999). "Immunohistochemical localization of carboxypeptidases E and D in the human placenta and umbilical cord.". J. Histochem. Cytochem. 46 (12): 1359–68. PMID 9815277.
Hadkar V, Skidgel RA (2001). "Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium.". Mol. Pharmacol. 59 (5): 1324–32. PMID 11306718.
Fan X, Olson SJ, Blevins LS, et al. (2003). "Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary.". J. Histochem. Cytochem. 50 (11): 1509–16. PMID 12417617.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kalinina EV, Fricker LD (2003). "Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.". J. Biol. Chem. 278 (11): 9244–9. PMID 12643288.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
O'Malley PG, Sangster SM, Abdelmagid SA, et al. (2006). "Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells.". Biochem. J. 390 (Pt 3): 665–73. doi:10.1042/BJ20050025. PMID 15918796.