Coxsackie virus and adenovirus receptor

From Wikipedia, the free encyclopedia

PDB rendering based on 1eaj.

Available structures: 1eaj, 1f5w, 1jew, 1kac, 1p69, 1p6a, 1rsf, 2j12, 2j1k, 2npl

Identifiers

Symbol(s)

CXADR; CAR; HCAR

External IDs

OMIM: 602621 MGI: 1201679 HomoloGene: 1024

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• plasma membrane • integral to plasma membrane • tight junction
Biological Process:	• mitochondrion organization and biogenesis • cell adhesion • heart development • cardiac muscle fiber development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001338 (mRNA)
NP_001329 (protein)

NM_001025192 (mRNA)
NP_001020363 (protein)

Location

Chr 21: 17.81 - 17.86 Mb

Chr 16: 78.18 - 78.22 Mb

Pubmed search

[1]

[2]

Coxsackie virus and adenovirus receptor, also known as CXADR, is a human gene.^[1]

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.^[1]

[edit] References

^ ^a ^b Entrez Gene: CXADR coxsackie virus and adenovirus receptor.

[edit] Further reading

Carson SD (2002). "Receptor for the group B coxsackieviruses and adenoviruses: CAR.". Rev. Med. Virol. 11 (4): 219–26. PMID 11479928.
Selinka HC, Wolde A, Sauter M, et al. (2004). "Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism.". Med. Microbiol. Immunol. 193 (2-3): 127–31. doi:10.1007/s00430-003-0193-y. PMID 12920584.
Bergelson JM, Cunningham JA, Droguett G, et al. (1997). "Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.". Science 275 (5304): 1320–3. PMID 9036860.
Tomko RP, Xu R, Philipson L (1997). "HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3352–6. PMID 9096397.
Carson SD, Chapman NN, Tracy SM (1997). "Purification of the putative coxsackievirus B receptor from HeLa cells.". Biochem. Biophys. Res. Commun. 233 (2): 325–8. doi:10.1006/bbrc.1997.6449. PMID 9144533.
Bergelson JM, Krithivas A, Celi L, et al. (1998). "The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.". J. Virol. 72 (1): 415–9. PMID 9420240.
Fechner H, Haack A, Wang H, et al. (2000). "Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers.". Gene Ther. 6 (9): 1520–35. doi:10.1038/sj.gt.3301030. PMID 10490761.
Bowles KR, Gibson J, Wu J, et al. (1999). "Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene.". Hum. Genet. 105 (4): 354–9. PMID 10543405.
Bewley MC, Springer K, Zhang YB, et al. (1999). "Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR.". Science 286 (5444): 1579–83. PMID 10567268.
Tomko RP, Johansson CB, Totrov M, et al. (2000). "Expression of the adenovirus receptor and its interaction with the fiber knob.". Exp. Cell Res. 255 (1): 47–55. doi:10.1006/excr.1999.4761. PMID 10666333.
van Raaij MJ, Chouin E, van der Zandt H, et al. (2001). "Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution.". Structure 8 (11): 1147–55. PMID 11080637.
Cohen CJ, Gaetz J, Ohman T, Bergelson JM (2001). "Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting.". J. Biol. Chem. 276 (27): 25392–8. doi:10.1074/jbc.M009531200. PMID 11316797.
Noutsias M, Fechner H, de Jonge H, et al. (2001). "Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections.". Circulation 104 (3): 275–80. PMID 11457744.
Thoelen I, Magnusson C, Tågerud S, et al. (2001). "Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene.". Biochem. Biophys. Res. Commun. 287 (1): 216–22. doi:10.1006/bbrc.2001.5535. PMID 11549277.
He Y, Chipman PR, Howitt J, et al. (2001). "Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor.". Nat. Struct. Biol. 8 (10): 874–8. doi:10.1038/nsb1001-874. PMID 11573093.
Cohen CJ, Shieh JT, Pickles RJ, et al. (2002). "The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15191–6. doi:10.1073/pnas.261452898. PMID 11734628.
Law LK, Davidson BL (2002). "Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor.". J. Virol. 76 (2): 656–61. PMID 11752156.
van't Hof W, Crystal RG (2002). "Fatty acid modification of the coxsackievirus and adenovirus receptor.". J. Virol. 76 (12): 6382–6. PMID 12021372.
Walters RW, Freimuth P, Moninger TO, et al. (2002). "Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape.". Cell 110 (6): 789–99. PMID 12297051.