COX7C

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit VIIc

Identifiers

External IDs

OMIM: 603774 MGI: 103226 HomoloGene: 81691

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • membrane • integral to membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001867 (mRNA)
NP_001858 (protein)

NM_007749 (mRNA)
NP_031775 (protein)

Location

Chr 5: 85.95 - 85.95 Mb

Chr 13: 86.52 - 86.52 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit VIIc, also known as COX7C, is a human gene.^[1]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX7C cytochrome c oxidase subunit VIIc.

[edit] Further reading

Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.". Prog. Nucleic Acid Res. Mol. Biol. 61: 309-44. PMID 9752724.
Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457-65. doi:10.1515/BC.2007.059. PMID 17516841.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hofmann S, Lichtner P, Schuffenhauer S, et al. (1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping.". Cytogenet. Cell Genet. 83 (3-4): 226-7. PMID 10072584.
Kaminishi H, Hamatake H, Cho T, et al. (1994). "Activation of blood clotting factors by microbial proteinases.". FEMS Microbiol. Lett. 121 (3): 327-32. PMID 7926688.
Koga Y, Fabrizi GM, Mita S, et al. (1990). "Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase.". Nucleic Acids Res. 18 (3): 684. PMID 2155413.
Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.". Eur. J. Biochem. 203 (1-2): 193-9. PMID 1309697.