COX7A1

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)

Identifiers

COX7A1; COX7A; COX7AH; COX7AM

External IDs

OMIM: 123995 MGI: 1316714 HomoloGene: 48051

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • electron carrier activity
Cellular Component:	• mitochondrion • mitochondrial respiratory chain • membrane • integral to membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001864 (mRNA)
NP_001855 (protein)

NM_009944 (mRNA)
NP_034074 (protein)

Location

Chr 19: 41.33 - 41.34 Mb

Chr 7: 29.89 - 29.89 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle), also known as COX7A1, is a human gene.^[1]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle).

[edit] Further reading

Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.". Prog. Nucleic Acid Res. Mol. Biol. 61: 309–44. PMID 9752724.
Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.". Eur. J. Biochem. 203 (1-2): 193–9. PMID 1309697.
Arnaudo E, Hirano M, Seelan RS, et al. (1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase.". Gene 119 (2): 299–305. PMID 1327965.
Fabrizi GM, Rizzuto R, Nakase H, et al. (1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase.". Nucleic Acids Res. 17 (17): 7107. PMID 2550906.
Wolz W, Kress W, Mueller CR (1998). "Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M.". Genomics 45 (2): 438–42. doi:10.1006/geno.1997.4937. PMID 9344674.
Schmidt TR, Goodman M, Grossman LI (1999). "Molecular evolution of the COX7A gene family in primates.". Mol. Biol. Evol. 16 (5): 619–26. PMID 10335655.
Yu M, Jaradat SA, Grossman LI (2002). "Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH).". Biochim. Biophys. Acta 1574 (3): 345–53. PMID 11997101.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.