COX5B

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit Vb

Identifiers

External IDs

OMIM: 123866 MGI: 88475 HomoloGene: 37538

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • zinc ion binding • oxidoreductase activity • metal ion binding
Cellular Component:	• mitochondrion • mitochondrial envelope • membrane
Biological Process:	• electron transport • respiratory gaseous exchange

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001862 (mRNA)
NP_001853 (protein)

NM_009942 (mRNA)
NP_034072 (protein)

Location

Chr 2: 97.63 - 97.63 Mb

Chr 13: 21.51 - 21.51 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit Vb, also known as COX5B, is a human gene.^[1]

Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX5B cytochrome c oxidase subunit Vb.

[edit] Further reading

Lomax MI, Hsieh CL, Darras BT, Francke U (1991). "Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes.". Genomics 10 (1): 1–9. PMID 1646156.
Romero N, Marsac C, Fardeau M, et al. (1990). "Immunohistochemical demonstration of fibre type-specific isozymes of cytochrome c oxidase in human skeletal muscle.". Histochemistry 94 (2): 211–5. PMID 2162812.
Zeviani M, Sakoda S, Sherbany AA, et al. (1988). "Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase.". Gene 65 (1): 1–11. PMID 2840351.
Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993.". Electrophoresis 14 (11): 1216–22. PMID 8313870.
Bachman NJ, Yang TL, Dasen JS, et al. (1996). "Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter.". Arch. Biochem. Biophys. 333 (1): 152–62. doi:10.1006/abbi.1996.0376. PMID 8806766.
Lefai E, Vincent A, Boespflug-Tanguy O, et al. (1997). "Quantitative decrease of human cytochrome c oxidase during development: evidences for a post-transcriptional regulation.". Biochim. Biophys. Acta 1318 (1-2): 191–201. PMID 9030264.
Wu H, Rao GN, Dai B, Singh P (2000). "Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3.". J. Biol. Chem. 275 (42): 32491–8. doi:10.1074/jbc.M002458200. PMID 10915781.
Beauchemin AM, Gottlieb B, Beitel LK, et al. (2002). "Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy.". Brain Res. Bull. 56 (3-4): 285–97. PMID 11719263.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.