Talk:Cortisone
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[edit] Cortisone != cortisol
As far as I can judge, this article describes the hormone cortisol not cortisone. Cortisone, in my vocabulary, is a medical substance acting like cortisol. I am however not bold enough to go ahead mess around with this in English, not being a native English speaker - but if no objections arrive I will adjust this article according to my view on the subject. // Habj 19:59, 21 January 2006 (UTC)
AFAIK, cortisone is synthetic cortisol. Also, Corticosterone is refered to here as unimportant. Yes, in human health as humans do not express it: It is the rodent version of cortisol. The claim that cortisol/cortisone is responsible for stress/ill-health correlation is oversimplistic. 1. In chronic stress cort. becomes downregulated and AVP becomes the major driver of the HPA axis, and hence the major driver of immune inhibition; 2. The autonomic nervous system also plays a major role in damping down immune responses during stress; 3. Autoimmune diseases actually benefit from high cortisol levels. There are many other substances that mediate immune supression eg substance P, NF kappa beta etc. It seems to be a problem here that the chemistry project run pages on biological molecules are over-simplistic wrt to the biology. Is there no biochemistry/cellular biology project similar to the chemistry one? I support the above edit.Povmcdov 15:47, 25 February 2007 (UTC)
[edit] Image found on commons
—The preceding unsigned comment was added by Leonard G. (talk • contribs) 06:45, 19 December 2006 (UTC).
Be careful! There is a mistake in the article: this is not a steroid-like structure on the picture! Look on the right for the structure:
- Both the image in the article and the image on this page represent the same chemical compound - and they both have steroid structure. I don't see a mistake in either. The one in the article, however, is preferred because it contains additional stereochemical information that is not present in this one. --Ed (Edgar181) 14:52, 30 April 2007 (UTC)
[edit] Uses?
Effects and Uses section is weak. What are the uses? It seems there are some paragraphs missing. The 3rd paragraph begins: "One of cortisone's effects on..." -- it seems the writer assumes we already know what cortisone is used for, when he starts talking about side-effects. But his previous 2 paragraphs have nothing to that effect.
All that he says (in the preceding para) is: "...sometimes used as a drug to treat a variety of ailments..." -- duh? Of course it is; but .. what ailments? And how? Details, details.
Very surprising that this is omitted; the largest part of any Wiki article about any drug should be what it is used for. I understand that cortisone is used for arthritis; can this be confirmed? There should be an entire section devoted to this, if so.
Lots of work needed to clean this article up, I'm afraid. —Preceding unsigned comment added by Atikokan (talk • contribs) 01:04, 9 March 2008 (UTC)
I am interested in potential side effects. Some years ago my doctor injected both my shoulders and elbows with cortisone because I had severe inflamation in the joints. Within weeks I gained about 60 pounds in weight and despite dieting I am unable to lose the extra weight. Yet doctors insist that my weight gain is not related to the injections. The Geologist (talk) 13:22, 11 March 2008 (UTC)
[edit] Lewis Hastings Sarett
Should Lewis Hastings Sarett be mentioned? He was th chemist at Merck doing the synthesis?--Stone (talk) 14:38, 24 May 2008 (UTC)
