Cortisol sulfotransferase

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In enzymology, a cortisol sulfotransferase (EC 2.8.2.18) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + cortisol $\rightleftharpoons$ adenosine 3',5'-bisphosphate + cortisol 21-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and cortisol, whereas its two products are adenosine 3',5'-bisphosphate and cortisol 21-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase. Other names in common use include glucocorticosteroid sulfotransferase, and glucocorticoid sulfotransferase.

[edit] References

IUBMB entry for 2.8.2.18
BRENDA references for 2.8.2.18 (Recommended.)
PubMed references for 2.8.2.18
PubMed Central references for 2.8.2.18
Google Scholar references for 2.8.2.18
Singer SS, Brill B (1982). "Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol". Biochim. Biophys. Acta. 712: 590–6. PMID 6957246.
Singer SS, Giera D, Johnson J, Sylvester S (1976). "Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations". Endocrinology. 98: 963–74. PMID 1278101.