From Wikipedia, the free encyclopedia
| Coronavirus frameshifting stimulation element |
 |
| Type: |
Cis-reg; frameshift_element; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
82.5 nucleotides |
| Avg identity: |
80% |
|
In molecular biology, the coronavirus frameshifting stimulation element is a conserved stem-loop of RNA found in coronaviruses that can promote ribosomal frameshifting. Such RNA molecules interact with a downstream region to form a pseudoknot structure; the region varies according to the virus but pseudoknot formation is known to stimulate frameshifting. In the classical situation, a sequence 32 nucleotides downstream of the stem is complementary to part of the loop. In other coronaviruses, however, another stem-loop structure around 150 nucleotides downstream can interact with members of this family to form kissing stem loops and stimulate frameshifting.[1]
[edit] References
- ^ Baranov, PV; Henderson CM, Anderson CB, Gesteland RF, Atkins JF, Howard MT (2005). "Programmed ribosomal frameshifting in decoding the SARS-CoV genome". Virology 332: 498–510. doi:10.1016/j.virol.2004.11.038. PMID 15680415.
[edit] External links
