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| Coronavirus 3' UTR pseudoknot |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
62.5 nucleotides |
| Avg identity: |
70% |
|
The Coronavirus 3' UTR pseudoknot is an RNA structure found in the coronavirus genome. Coronaviruses contain 30 kb single-stranded positive-sense RNA genomes. The 3' UTR region of these coronavirus genomes contains a conserved ~55 nucleotide pseudoknot structure which is necessary for viral genome replication.[1] The mechanism of cis-regulation is unclear, but this element is postulated to function in the plus-strand.
[edit] References
- ^ Williams, GD; Chang RY, Brian DA (1999). "A phylogenetically conserved hairpin-type 3' untranslated region pseudoknot functions in coronavirus RNA replication". J Virol 73: 8349–8355. PMID 10482585.
[edit] External links
