Copalyl diphosphate synthase

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In enzymology, a copalyl diphosphate synthase (EC 5.5.1.12) is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate $\rightleftharpoons$ (+)-copalyl diphosphate

Hence, this enzyme has one substrate, geranylgeranyl diphosphate, and one product, (+)-copalyl diphosphate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is (+)-copalyl-diphosphate lyase (decyclizing). This enzyme participates in diterpenoid biosynthesis.

[edit] References

IUBMB entry for 5.5.1.12
BRENDA references for 5.5.1.12 (Recommended.)
PubMed references for 5.5.1.12
PubMed Central references for 5.5.1.12
Google Scholar references for 5.5.1.12
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Ravn MM, Peters RJ, Coates RM, Croteau R (2002). "Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates". J. Am. Chem. Soc. 124: 6998–7006. doi:10.1021/ja017734b. PMID 12059223.
Peters RJ, Croteau RB (2002). "Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate". Biochemistry. 41: 1836–42. doi:10.1021/bi011879d. PMID 11827528.