COPS6

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COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Identifiers
Symbol(s) COPS6; MOV34-34KD
External IDs MGI: 1349439 HomoloGene: 4977
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10980 26893
Ensembl ENSG00000168090 ENSMUSG00000019494
Uniprot Q7L5N1 Q3UIT2
Refseq NM_006833 (mRNA)
NP_006824 (protein)		 NM_012002 (mRNA)
NP_036132 (protein)
Location Chr 7: 99.52 - 99.53 Mb Chr 5: 138.39 - 138.39 Mb
Pubmed search [1] [2]

COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis), also known as COPS6, is a human gene.

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.[1]

[edit] References

  1. ^ Entrez Gene: COPS6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis).

[edit] Further reading

  • Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295. 
  • Muthumani K, Choo AY, Premkumar A, et al. (2006). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.". Cell Death Differ. 12 Suppl 1: 962–70. doi:10.1038/sj.cdd.4401583. PMID 15832179. 
  • Mittmeyer HJ (1976). "[Distribution pattern of rigor mortis in various joint regions]". Beitr. Gerichtl. Med. 33: 85–96. PMID 1222062. 
  • He J, Choe S, Walker R, et al. (1995). "Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity.". J. Virol. 69 (11): 6705–11. PMID 7474080. 
  • Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.". J. Virol. 69 (11): 6859–64. PMID 7474100. 
  • Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.". J. Virol. 69 (12): 7909–16. PMID 7494303. 
  • Jowett JB, Planelles V, Poon B, et al. (1995). "The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle.". J. Virol. 69 (10): 6304–13. PMID 7666531. 
  • Zhao LJ, Mukherjee S, Narayan O (1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.". J. Biol. Chem. 269 (22): 15577–82. PMID 8195203. 
  • Poon B, Jowett JB, Stewart SA, et al. (1997). "Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.". J. Virol. 71 (5): 3961–71. PMID 9094673. 
  • Asano K, Vornlocher HP, Richter-Cook NJ, et al. (1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.". J. Biol. Chem. 272 (43): 27042–52. PMID 9341143. 
  • Mahalingam S, Ayyavoo V, Patel M, et al. (1998). "HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419–24. PMID 9520381. 
  • Seeger M, Kraft R, Ferrell K, et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.". FASEB J. 12 (6): 469–78. PMID 9535219. 
  • Wei N, Tsuge T, Serino G, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.". Curr. Biol. 8 (16): 919–22. PMID 9707402. 
  • Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877. 
  • Elder RT, Yu M, Chen M, et al. (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint.". Virus Res. 68 (2): 161–73. PMID 10958988. 
  • Ramanathan MP, Ayyavoo V, Weiner DB (2001). "Choice of expression vector alters the localization of a human cellular protein.". DNA Cell Biol. 20 (2): 101–5. doi:10.1089/104454901750070300. PMID 11244567. 
  • Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMID 11285227. 
  • Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.". Science 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588. 
  • Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413. 
  • Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMID 12110603. 
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