COPB2

From Wikipedia, the free encyclopedia

Coatomer protein complex, subunit beta 2 (beta prime)

Identifiers

COPB2; beta'-COP

External IDs

OMIM: 606990 MGI: 1354962 HomoloGene: 3499

Gene ontology
Molecular Function:	• protein transporter activity
Cellular Component:	• endoplasmic reticulum • Golgi apparatus • membrane • COPI vesicle coat
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport • retrograde vesicle-mediated transport, Golgi to ER • intra-Golgi vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004766 (mRNA)
NP_004757 (protein)

NM_015827 (mRNA)
NP_056642 (protein)

Location

Chr 3: 140.56 - 140.59 Mb

Chr 9: 98.38 - 98.4 Mb

Pubmed search

[1]

[2]

Coatomer protein complex, subunit beta 2 (beta prime), also known as COPB2, is a human gene.^[1]

The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: COPB2 coatomer protein complex, subunit beta 2 (beta prime).

[edit] Further reading

Pelham HR, Rothman JE (2000). "The debate about transport in the Golgi--two sides of the same coin?". Cell 102 (6): 713–9. PMID 11030615.
Stenbeck G, Harter C, Brecht A, et al. (1993). "beta'-COP, a novel subunit of coatomer.". EMBO J. 12 (7): 2841–5. PMID 8334999.
Harrison-Lavoie KJ, Lewis VA, Hynes GM, et al. (1993). "A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins.". EMBO J. 12 (7): 2847–53. PMID 8335000.
Lowe M, Kreis TE (1996). "In vitro assembly and disassembly of coatomer.". J. Biol. Chem. 270 (52): 31364–71. PMID 8537409.
Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor.". J. Biol. Chem. 271 (48): 30725–30. PMID 8940050.
Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D (1997). "The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon.". J. Biol. Chem. 272 (46): 29200–6. PMID 9360998.
De Baere E, Speleman F, Van Roy N, et al. (1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization.". Cytogenet. Cell Genet. 82 (3-4): 226–7. PMID 9858824.
Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMID 10921873.
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.". Mol. Biol. Cell 11 (9): 3155–68. PMID 10982407.
Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport.". J. Biol. Chem. 276 (29): 27480–7. doi:10.1074/jbc.M102786200. PMID 11323436.
Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.". Mol. Biol. Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMID 12388752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Rohde HM, Cheong FY, Konrad G, et al. (2004). "The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex.". J. Biol. Chem. 278 (52): 52689–99. doi:10.1074/jbc.M307983200. PMID 14527956.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.